Effect of GH and insulin on the generation of somatomedin by perfused rat liver.

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概要

• 論文の詳細を見る

• The release of somatomedin from perfused livers of normal and hypophysectomized (hypox) rats has been studied. Somatomedin was determined by the radioreceptor assay for somatomedin A. The release of somatomedin in the perfusates of normal livers was observed during the initial 30minutes and maintained during the second and third 30 minutes of recirculation. The addition of insulin at a concentration of 10mU/ml to the perfusates caused a significant increase in the release of somatomedin in the 1st, 2nd and 3rd 30-minute recirculatory perfusates. The addition of human growth hormone (25μg/ml) and/or insulin (1mU/ml) to the perfusates caused a significant increase in somatomedin after 120minutes of recirculation. Hypox rats released amounts of somatomedin in perfusates similar to those of normal rats. The effect of insulin on the release of somatomedin was greater in hypox rats than that observed in normal rats.<BR>The molecular size of the somatomedin released in the perfusate was greater than that of purified somatomedin, suggesting that this somatomedin is bound to carrier proteins.

• 社団法人 日本内分泌学会の論文

著者

• Takano Kazue

  Department Of Endocrinology Clinical Institute Of Endocrinology Tokyo Women's Medical Universit

• Asakawa Kumiko

  Department Of Medicine Institute Of Clinical Endocrinology Tokyo Women's College

• SHIZUME KAZUO

  Department of Endocrinology and Endocrine Research Laboratory Toranomon Hospital

• HIZUKA NAOMI

  Department of Internal Medicine Tokyo Women's Medical College

• KOGAWA MEGUMI

  Department of Medicine Tokyo Women's Medical College

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