Effect of thyroid hormone on the serum level of somatomedin A.
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概要
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The effect of thyroid hormone on the serum level of somatomedin A was studied using a radioreceptor assay for somatomedin A. In 13 patients with hyperthyroidism, the mean level of somatomedin A was 0.60±0.05U/ml, which was within the normal range. Low levels were found in 19 patients with primary hypothyroidism with a mean of 0.39±0.04 U/m<I>l</I>. After treating these patients with thyroxine, the serum somatomedin A levels returned to the normal range. There was a significant correlation between the somatomedin A level on one hand and T<SUB>3</SUB> (r=0.49) and T<SUB>4</SUB> (r=0.55) level on the other.<BR>The serum level of somatosmedin A did not decrease for 7 days after thyroidectomy nor increase after treating hypophysectomized rats with 2 μg of thyroxine for 14 days. However, the effect of growth hormone on serum somatomedin A was augmented 42.2% by the combined administration of the same amount of T<SUB>4</SUB> for 7 days. There was a positive correlation between the serum level of somatomedin A and the percentage increase in body weight (r=0.73). These data suggest that thyroxine potentiates the effect of GH on synthesis and/or the secretion of somatome din A.
- 社団法人 日本内分泌学会の論文
著者
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Takano Kazue
Department Of Endocrinology Clinical Institute Of Endocrinology Tokyo Women's Medical Universit
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SHIZUME KAZUO
Department of Endocrinology and Endocrine Research Laboratory Toranomon Hospital
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KOGAWA MEGUMI
Department of Medicine, Tokyo Women's Medical College
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TSUSHIMA TOSHIO
Department of Endocrinology and Endocrine Research Laboratory Toranomon Hospital
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HIZUKA NAOMI
Department of Internal Medicine Tokyo Women's Medical College
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HIZUKA NAOMI
Department of Medicine Tokyo Women's Medical College
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HASUMI YOKO
Department of Medicine Tokyo Women's Medical College
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KOGAWA MEGUMI
Department of Medicine Tokyo Women's Medical College
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TSUSHIMA TOSHIO
Department of Medicine Tokyo Women's Medical College
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