Time Course of Distribution to Tissues of <SUP>125</SUP>I -Somatomedin A Injected into the Rat
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概要
- 論文の詳細を見る
<SUP>125</SUP>I-somatomedin A (SMA) was injected iv into rats. Distribution studies in rats showed concentrations of radioactivity to be high in kidney and plasma, low in brain, and intermediate in other tissues. The concentration of total and trichloracetic acid (TCA) precipitable radioactivity in rat blood and tissues fell at rapid rate. Ninety per cent of the radioactivity was in the urine in 24hr, and only 15% of urine radioactivity was TCA precipitable. The half-life of the radioactivity in TCAprecipitable fraction from blood and that from tissues were nearly identical (about 6hr). In both liver and kidney, TCA-precipitable radioactivity was detected in membrane and/or organellar fraction and cytosol fraction. Sephadex G-200 chromatography at neutral pH of plasma after injection of<SUP>125</SUP>I-SMA revealed3peaks of radioactivity in higher molecular weight region than purified SMA.
- 社団法人 日本内分泌学会の論文
著者
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Hizuka Naomi
Department Of Medicine And Gastroenterology Tokyo Women's Medical University
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Takano Kazue
Department Of Endocrinology Clinical Institute Of Endocrinology Tokyo Women's Medical Universit
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Shizume Kazuo
Department of Internal Medioine Tokyo Women's Medical College
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Kawai Koichi
Department Of Chemistry
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Kawai K
Univ. Tsukuba
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SHIZUME KAZUO
Department of Endocrinology and Endocrine Research Laboratory Toranomon Hospital
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KAWAI KOICHI
Department of Internal Medicine Tokyo Women's Medical College
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TAKANO KAZUE
Department of Internal Medicine Tokyo Women's Medical College
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HIZUKA NAOMI
Department of Internal Medicine Tokyo Women's Medical College
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