Effect of human growth hormone on serum somatomedin A in patients with growth hormone deficiency.
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概要
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Serum somatomedin A was determined by a radioreceptor assay in six patients with GH deficiency before and after im administration of GH in doses between 0.5 and 8mg. The mean basal value of somatomedin A, 0.36±0.02 U/m<I>l</I> (mean±SEM), was significantly lower than that of age-matched controls, 0.82±0.02 U/m<I>l</I>. There was no diurnal variation. Somatomedin A levels increased significantly eight hours after GH administration, remained elevated for 48 hours and returned to basal levels after 72 hours. The mean levels of somatomedin A found 24 hours after 1, 2, 4 and 8 mg of GH were 0.45±0.05, 0.68±0.10, 0.71±0.08 and 1.03±0.02 U/m<I>l</I>, respectively. A linear dose-response curve between the logarithmic dose of GH and the somatomedin A increase was found in three of six patients.
- 社団法人 日本内分泌学会の論文
著者
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Takano Kazue
Department Of Endocrinology Clinical Institute Of Endocrinology Tokyo Women's Medical Universit
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SHIZUME KAZUO
Department of Endocrinology and Endocrine Research Laboratory Toranomon Hospital
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HALL KERSTIN
Department of Endocrinology, Karolinska Hospital
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HIZUKA NAOMI
Department of Internal Medicine Tokyo Women's Medical College
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