Effect of Hypophysectomy on Hypothalamic Somatostatin Content in Rats
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概要
- 論文の詳細を見る
The effect of hypophysectomy on the hypothalamic somatostatin content was examined in rats. Somatostatin content in the acid extract of the pituitary stalk and the median eminence tissue (SME) was measured by specific radioimmunoassay.<BR>In young male rats, the mean somatostatin content in SME was 63.9±5.0ng. Two weeks after hypophysectomy, it was reduced significantly to 34.4±3.3ng.<BR>The result may indicate that the elimination of feedback actions of GH and/or TSH on the hypothalamus led to the decreased synthesis and/or the release of somatostatin. However, the possibility that structural changes in the pituitary stalk and the median eminence tissue ensued after hypophysectomy resulted in the depletion of somatostatin cannot be ruled out.
- 社団法人 日本内分泌学会の論文
著者
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Demura Hiroshi
Department Of Internal Medicine Institute Of Clinical Endocrinology Tokyo Women's Medical Colle
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Shizume Kazuo
Department of Internal Medioine Tokyo Women's Medical College
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Demura Reiko
Department Of Environmental Hygiene School Of Pharmacy Hokuriku University
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Wakabayashi Ichiji
Department Of Internal Medicine Tokyo Women's Medical College
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Wakabayashi Ichiji
Department Of Internal Medicine 3 Nippon Medical School
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KANDA MEGUMI
Department of Internal Medicine, Tokyo Womens Medical College
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SHIZUME KAZUO
Department of Endocrinology and Endocrine Research Laboratory Toranomon Hospital
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KANDA MEGUMI
Department of Internal Medicine Tokyo Women's Medical College
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DEMURA HIROSHI
Department of Internal Medicine Tokyo Women's Medical College
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DEMURA REIKO
Department of Internal Medicine Tokyo Women's Medical College
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