Long-term Result of Antithyroid Drug Therapy for Graves Disease : Follow up after more than 5 years
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概要
- 論文の詳細を見る
From 1955 to 1963, 159 cases of Graves disease were treated with antithyroid drugs for more than 6 months. This report concerns the outcome of these cases in 1969. Among 159 patients treated with antithyroid drugs, the present status could be studied in 86 cases. In these 86 cases, 24 were in remission for more than 2 years after the discontinuance of antithyroid drug therapy, 4 were in remission less than 2 years after the discontinuance of antithyroid drug therapy, 1 case was still hyperthyroid, 9 cases were still receiving antithyroid drugs, 6 underwent an operation because of recurrence, and 24 underwent 131t therapy because of recurrence. Remission rate after the administration of antithyroid drug for less than one year was 24%. In recurrent cases after further administration for 2 to 6 years, 10-20% of the patients experienced prolonged remission. In order to find out the factors related to permanent remission, 42 patients with permanent remission and 40 patients who failed permanent remission were compared in several factors.<BR>From these studies, the incidence of permanent remission seems to be high in the following cases. 1) small goiter 2) short duration of symptoms 3) reduction in the size of the goiter during the treatment 4) positive suppression by thyroid suppression test at the conclusion of treatment. It was also observed that in cases in which antithyroid drug therapy was not effective after one year, further treatment for 2 to 5 years led to permanent remission in some cases. However, such a possibility is very small after more than 6 years of treatment.<BR>The authors have 9 patients who have been taking small doses of antithyroid drugs for 5 to 12 years and working well in euthyroid conditions. Considering the shortcomings of surgery and <SUP>131</SUP>I therapy, this kind of treatment might be appropriate in some cases.
- 社団法人 日本内分泌学会の論文
著者
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Irie Minoru
Department Of Internal Medicine School Of Medicine Toho University
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Nagataki Shigenobu
Department Of Internal Medicine School Of Medicine Tokyo University.
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Tsushima Toshio
Department Of Endocrinology Clinical Institute Of Endocrinology Tokyo Women's Medical Universit
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Shizume Kazuo
Department of Internal Medioine Tokyo Women's Medical College
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SHISHIBA YOSHIMASA
Department of Endocrinology and Metabolism
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Suematsu Hiroyuki
Department Of Psychosomatic Medicine Branch Hospital Faculty Of Medicine The University Of Tokyo
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MATSUZAKI FUKASHI
Department of Endocrinology and Endocrine Research Laboratory, Toranomon Hospital
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SUEMATSU HIROYUKI
Department of Endocrinology and Endocrine Research Laboratory Toranomon Hospital
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SUEMATSU Hiroyuki
Department of Clinical Laboratory, JA Gifu Koseiren Chuno General Hospital
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SHIZUME KAZUO
Department of Endocrinology and Endocrine Research Laboratory Toranomon Hospital
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TSUSHIMA TOSHIO
Department of Endocrinology and Endocrine Research Laboratory Toranomon Hospital
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NAGATAKI SHIGENOBU
Department of Endocrinology and Endocrine Research Laboratory Toranomon Hospital
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IRIE MINORU
Department of Endocrinology and Endocrine Research Laboratory Toranomon Hospital
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MATSUZAKI FUKASHI
Department of Endocrinology and Endocrine Research Laboratory Toranomon Hospital
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SHISHIBA YOSHIMASA
Department of Endocrinology and Endocrine Research Laboratory Toranomon Hospital
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