Properties and Concentrations of Somatomedin A in Various Rat Tissues
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概要
- 論文の詳細を見る
The concentration of somatomedin A (SMA) in various rat tissues was determined directly by the radioreceptor assay in supernates of tissue homogenates at 100, 000×g for 60 min. The SMA concentrations in pancreas, kidney, lung, liver, spleen, testis, brain and muscle were 2.56, 2.40, 2.28, 2.16, 1.56, 1.44, 0.60 and 0.30U/g of wet tissue, respectively. The SMA content in rat serum was 6.66U/m<I>l</I>. The SMA concentration in tissues never exceeded that in serum. When the100, 000×g pellet of liver was treated with a hypotonic solution, the SMA content in the hypotonic solution was about 35% of that in the initial supernate. This result indicates that about30% of the SMA in liver was stored in organellae. SMA in tissues decreased with incubation at 37°C, though SMA in serum did not. This decrease could be precluded by adding 0.75mm HgCl<SUB>2</SUB> to the liver homogenate. The SMA content of the liver homogenate was dependent on growth hormone in experiments both <I>in vivo</I> and in vitro.
- 社団法人 日本内分泌学会の論文
著者
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Hizuka Naomi
Department Of Medicine And Gastroenterology Tokyo Women's Medical University
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Takano Kazue
Department Of Endocrinology Clinical Institute Of Endocrinology Tokyo Women's Medical Universit
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Shizume Kazuo
Department of Internal Medioine Tokyo Women's Medical College
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Kawai Koichi
Department Of Chemistry
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Kawai K
Univ. Tsukuba
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SHIZUME KAZUO
Department of Endocrinology and Endocrine Research Laboratory Toranomon Hospital
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KAWAI KOICHI
Department of Internal Medicine, Tokyo Women's Medical College
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HIZUKA NAOMI
Department of Internal Medicine Tokyo Women's Medical College
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HIZUKA NAOMI
Department of Internal Medicine, Tokyo Women's Medical College
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