Induction of specific human growth hormone binding sites in rat liver by human growth hormone.
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概要
- 論文の詳細を見る
<SUP>125</SUP>I-Labeled hGH was bound to liver plasma membranes which were obtained from female rats. The binding was displaced by hGH, hPRL, bPRL, rPRL and bGH but not by rGH. This result indicated that hGH was bound to lactogenic binding sites in rat livers. After hypophysectomy, the binding was markedly decreased. Treatment of hypophysectomized rats with hGH (80μg/day) for10days increased the binding sites for hGH. These binding sites were different from those found in normal female rat livers because of their high affinity and specificity for hGH. These results indicate that hGH induces specific binding sites for hGH in rat livers.
- 社団法人 日本内分泌学会の論文
著者
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Takano Kazue
Department Of Endocrinology Clinical Institute Of Endocrinology Tokyo Women's Medical Universit
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Kawai Koichi
Department Of Chemistry
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SHIZUME KAZUO
Department of Endocrinology and Endocrine Research Laboratory Toranomon Hospital
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KAWAI KOICHI
Department of Medicine Tokyo Women's Medical College
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HIZUKA NAOMI
Department of Internal Medicine Tokyo Women's Medical College
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