A Female Case of the HCG-Producing Ectopic Pinealoma Associated with Precocious puberty
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概要
- 論文の詳細を見る
A female case of precocious puberty associated with HCG-producing ectopic pinealoma was reported. The patient, a 5-year-old girl, was referred to the hospital because of headache and choked discs. Physical examination revealed normal physical growth with breast enlargement. Endocrinological study revealed a high plasma HCG concentration of 1192ng/m<I>l</I> with a normal FSH level. None of HCG, LH and FSH did respond to the LH-RH test. A partial resection of the tumor and an external X-ray irradiation relieved the symptoms and breast enlargement subsided with a remarkable decrease in the plasma HCG level. Histological examination revealed two-cell-pattern pinealoma and electron microscopic findings showed abundant secretory granules in the dark cells. HCG content in the tumor was as high as 400ng/mg of acetone dried tumor tissue, but no FSH was detectable. Hitherto, all of the reported cases of precocious puberty associated with pineal tumors have been exclusively boys. A normal level of plasma FSH concentration with a somewhat elevated prolactin level might be a contributory factor for the development of precocial sexual development in the present case.
- 社団法人 日本内分泌学会の論文
著者
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出村 黎子
東京女子医科大学ラジオアイソトープ科
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Kubo Osami
Department Of Neurosurgery Institute Of Clinical Neurology Tokyo Women's Medical University
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KITAMURA Koichi
Department of Neurological Surgery,Tokyo Women's Medical College
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Demura Hiroshi
Department Of Internal Medicine Institute Of Clinical Endocrinology Tokyo Women's Medical Colle
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Shizume Kazuo
Department of Internal Medioine Tokyo Women's Medical College
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Demura Reiko
Department Of Environmental Hygiene School Of Pharmacy Hokuriku University
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Demura Reiko
The Department Of Medicine Institute Of Clinical Endocrinology
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Kitamura Koichi
Department Of Neruosurgery Neurolofixl Institute Tokyo Women's Medical College
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