Growth Hormone and Prolactin in Tissue Culture of Pituitary Adenoma

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概要

• 論文の詳細を見る

• Pituitary adenomas obtained from 6 patients with acromegaly and 8 patients with chromophobe adenoma were subjected to the tissue culture to correlate <I>in vitro</I> secretion of growth hormone (GH) and prolactin (PRL) to preoperative in vivo endocrine studies and endocrinilogical manifestations. Tissue culture demonstrated that all of the acromegalic tumors secreted large amounts of GH for 2-4 weeks and some of the PRL-secreting chromophobe adenoma without any clinical and endocrinological evidences of GH secretion secreted considerable amounts of GH; however, no recognizable GH secretion was noted in the remaining chromophobe adenomas. PRL was secreted <I>in vitro</I> in large amounts by tumors obtained from patients with hyperprolactinemia with and without acromegaly. It is interesting to note that tumors obtained from 2 patients who showed very slight elevation of plasma PRL of less than 40ng/ml secreted large amounts of PRL <I>in vitro</I>. This finding suggests that PRL-secreting adenoma could not be ruled out in patients with mild hyperprolactinemia. The duration of <I>in vitro</I> PRL release was longer than that of GH and its rate of decrease was slower than that of GH.

• 社団法人 日本内分泌学会の論文

著者

• 出村 黎子

  東京女子医科大学ラジオアイソトープ科

• Demura Hiroshi

  Dept. Of Intern. Med. Tohoku Univ. Sch. Of Med.

• WAKABAYASHI Ichiji

  Dept. of lot. Med., Tokyo Women's Med. Col.

• Demura Reiko

  The Department Of Medicine Institute Of Clinical Endocrinology

• DEMURA REIKO

  Dept. of Internal Medicine, Tokyo Womens Medical College

• KUBO OSAMI

  Dept. of Neurological Surgery, Neurological nstitute Tokyo Womens Medical College

• ODAGIRI EMI

  Dept. of Internal Medicine, Tokyo Womens Medical College

• NOMURA KAORU

  Dept. of Internal Medicine, Tokyo Womens Medical College

• YAMAGUCHI HAJIME

  Dept. of Internal Medicine, Tokyo Womens Medical College

• SHIZUME KAZUO

  Dept. of Internal Medicine, Tokyo Womens Medical College

• YAMAGUCHI HAJIME

  Dept. of Internal Medicine, Tokyo Women's Medical College

• DEMURA REIKO

  Dept. of Internal Medicine, Tokyo Women's Medical College

• ODAGIRI EMI

  Dept. of Internal Medicine, Tokyo Women's Medical College

• WAKABAYASHI ICHIJI

  Dept. of Internal Medicine, Tokyo Women's Medical College

• DEMURA HIROSHI

  Dept. of Internal Medicine, Tokyo Women's Medical College

• KUBO OSAMI

  Dept. of Neurological Surgery, Neurological nstitute Tokyo Women's Medical College

• SHIZUME KAZUO

  Dept. of Internal Medicine, Tokyo Women's Medical College

• NOMURA KAORU

  Dept. of Internal Medicine, Tokyo Women's Medical College

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