Growth Rate of Intracranial Meningioma : Tumor Doubling Time and Proliferating Cell Nuclear Antigen Staining Index
スポンサーリンク
概要
- 論文の詳細を見る
The relationship between tumor doubling time, estimated by serial computed tomography (CT), and the proliferating cell nuclear antigen (PCNA) staining index of the tumor specimen was analyzed in 12 patients with nine partially or subtotally resected meningiomas and three meningiomas which recurred after gross total removal. There were nine meningothelial and three fibrous meningiomas. Malignant meningiomas and hemangiopericytomas were excluded. Serial CT was performed at various intervals ranging from 354 to 2007 days. Formalin-fixed, paraffin-embedded archival tissues were immunohistochemically stained using the avidin-biotin complex method with monoclonal antibody against PCNA. Percentages of PCNA-positive cells were calculated in 10 microscopic fields to determine the mean PCNA staining index. PCNA staining indexes varied from 0.13% to 7.46%. The tumor doubling time ranged from 197 to 7943 days and demonstrated a significant inverse rank correlation with the PCNA staining index (r = -0.89, p = 0.003). Meningiomas with PCNA staining indexes higher than 1% have comparatively short tumor doubling times of less than 5 years. PCNA immuno-staining is a useful method for evaluating the proliferative activity of meningiomas.
- 日本脳神経外科学会の論文
- 1995-05-15
著者
-
KUBO Osami
Department of Neurosurgery, Neurological Institute of Tokyo Women's Medical University
-
井出 光信
東京女子医科大学附属第二病院脳神経外科
-
YAMAMOTO Masaaki
Department of Neurosurgery, Fukuoka University School of Medicine
-
Yamamoto Masaaki
Department Of Neurosurgery Tokyo Women's Medico] University Daini Hospital
-
Kubo Osami
Department Of Neurosurgery Institute Of Clinical Neurology Tokyo Women's Medical University
-
IDE Mitsunobu
Department of Neurosurgery, Tokyo Women's Medico] University Daini Hospital
-
HAGIWARA Shinji
Department of Neurosurgery, Tokyo Women's Medico] University Daini Hospital
-
JIMBO Minoru
Departments of Neurosurgery, Tokyo Women's Medical College Dai-ni Hospital
-
UMEBARA Yutaka
Department of Neurosurgery, Dai-ni Hospital, Tokyo Women's Medical College
-
井出 光信
Department Of Neurosurgery Tokyo Women's Medico] University Daini Hospital
-
Umebara Yutaka
Department Of Neurosurgery Tokyo Women's Medical College Dai-ni Hospital
-
Jimbo Minoru
Departments Of Neurosurgery Tokyo Women's Medical College Dai-ni Hospital
-
Jimbo Minoru
Department Of Neurosurgery Faculty Of Medicine University Of Tokyo
-
Jimbo Minoru
Department Of Neurosurgery Neurological Institute Tokyo Women's Medical School
-
Hagiwara Shinji
Department Of Neurosurgery Tokyo Women's Medico] University Daini Hospital
-
Hagiwara Shinji
Department Of Neurosurgery Tokyo Women's Medical College Dai-ni Hospital
-
Hagiwara Shinji
Department Of International Medicine International Center For Medical Research Kobe University Schoo
-
Yamamoto Masaaki
Department Of Medicine Institute Of Clinical Endocrinology Tokyo Women's Medical University
-
Ide Mitsunobu
Departments Of Neurosurgery Tokyo Women's Medical College Dai-ni Hospital
-
Ide Mitsunobu
Department Of Neurosurgery Tokyo Women's Medical College Dai-ni Hospital
-
Yamamoto Masaaki
Department Of Dermatology Hyogo College Of Medicine
-
Yamamoto Masaaki
Department Of Neurosurgery Neurological Institute Tokyo Women's Medical School
-
KUBO Osami
Department of Neurosurgery, Neurological Institute, Tokyo Women's Medical College
-
Yamamoto Masaaki
Department of Chemistry, Faculty of Science, Kanazawa University
-
HAGIWARA SHINJI
Department of Environmental Chemistry, Utsunomiya University
関連論文
- Hemangiopericytoma in the Lateral Ventricle : Case Report
- Medium-sized AVMに対するガンマ・ナイフ治療の初期経験
- 髄膜炎を繰り返した外傷性髄液鼻漏の1例
- Cerebellar Gliomas with Exophytic Growth : Three Case Reports
- Symptomatic Chiari Malformation and Associated Pathophysiology in Pediatric and Adult Patients without Myelodysplasia
- Expression of Nuclear Factor-kB, Tumor Necrosis Factor Receptor Type 1, and c-Myc in Human Astrocytomas
- Intracranial Cavernous Angioma Manifesting as Subarachnoid Hemorrhage : Case Report
- Treatment of Bacterial Brain Abscess by Repeated Aspiration : Follow up by Serial Computed Tomography
- Direct Approach to the Ventrolateral Medulla for Cavernous Malformation : Case Report
- Rasmussen Syndrome : Multifocal Spread of Inflammation Suggested from MRI and PET Findings
- Rapid Regrowth of Intracranial Clear Cell Meningioma After Craniotomy and Gamma Knife Radiosurgery
- Immunohistochemical Study of Obliterated Arteriovenous Malformations after Gamma Knife Radiosurgery
- Tumor Cell Counting Using an Image Analysis Program for MIB-1 Immunohistochemistry
- Growth Rate of Intracranial Meningioma : Tumor Doubling Time and Proliferating Cell Nuclear Antigen Staining Index
- Gamma Knife Radiosurgery in Cerebral Arteriovenous Malformations: Report of Three Patients Treated Twice
- Meningioma Associated with Chronic Subdural Hematoma and Meningothelial Cell Cluster within the Hematoma Capsule : Case Report
- Solitary Pyogenic Thalamic Abscess : Two Case Reports
- Asymptomatic Calcified Chronic Subdural Hematoma : Report of Three Cases
- Posttraumatic Cerebral Arterial Spasm : Case Report
- Postoperative Neurosurgical Infection and Antibiotic Prophylaxis
- Peritumoral Brain Edema Associated with Meningioma : Histological Study of the Tumor Margin and Surrounding Brain
- Computerized Tomography in Acute Severe Head Trauma
- Expression of Inhibin α, and β_A Subunit and Activin Type II Receptor mRNAs in Various Human Pituitary Adenomas
- Expression of Type 5 Somatostatin Receptor in TSH-secreting Pituitary Adenomas : A Possible Marker for Predicting Longterm Response to Octreotide Therapy
- Demonstration of Activin in Normal Pituitary and in Various Human Pituitary Adenomas by Immunohistochemistry
- Inhibin α, β_Aand β_B Subunit Messenger Ribonucleic Acid Levels in Cultured Rat Pituitary: Studies by a Quantitative RT-PCR
- Aneurysmal bone cyst of the skull
- Hypothalamic Hamartoma Associated With Anterior Paraclinoid Aneurysm of the Internal Carotid Artery : Case Report
- 脳動脈瘤に対する内頸動脈結紮術施行後10年以上を経た2症例における各種画像診断所見
- Intracranial Epidermoid Tumor After Subcutaneous Lipoma Excision
- A-62. Ultrasturetures of Neuroectodermal Tumors : The Transitional Morphology between Medulloblastoma and Ependymoma
- Intrasellar Remote Metastasis from Adenoid Cystic Carcinoma of Parotid Gland : Case Report
- P4-20 Expression of p21(WAF1) protein in pituitary adenomas
- Primary Central Nervous System T-cell Lymphoma : Case Report
- Histopathological Study on Recurrent Low Grade Astrocytoma with Special Reference to MIB-1 and p53 Gene Expression
- Magnetic Resonance Imaging and Quantitative Analysis of Contents of Epidermoid and Dermoid Cysts
- Clinicopathological Study of Bacterial Intracranial Aneurysms
- A-63. Immunological Study of Brain Tumors : Immunological Function of Brain Tumor Patients
- Subepicranial Varix Mimicking Sinus Pericranii : Usefulness of Three-Dimensional Computed Tomography Angiography and Bone Window Computed Tomography
- Malignant Melanoma Arising From the Sphenoidal Sinus : Case Report
- Pseudoaneurysm Formation at the Rupture Site of a Middle Cerebral Artery Aneurysm(Case Report)
- Aneurysm of the Distal Posterior Inferior Cerebellar Artery Originating from the Extracranial and Extradural Vertebral Artery : Case Report
- Bilateral Ophthalmic Segment "Kissing" Aneurysms Presenting With Subarachnoid Hemorrhage : Case Report
- Transgenic Expression of VpreB-3 under the Control of the Immunoglobulin Heavy Chain Enhancer and SV40 Promoter
- Posterior Cerebral Artery Aneurysm Associated with Unilateral Internal Carotid Artery Agenesis : Case Report
- Determination of Target Point Magnification Rate on Stereotactic Angiography for Radiosurgery : Technical Note
- Successful treatment of postsurgical hypoparathyroidism by intramuscular injection of vitamin D_3 in a patient associated with malabsorption syndrome due to multiple abdominal surgeries
- 45. Relative Shunt Flow in Cerebral Arteriovenous Malformations
- S-H-3 S-H-3. Surgical Treatment of Cerebral Aneurysms and Arterio-venous Malformations : With Special Reference to Artificial Embolization (Symposium H: Intracranial Aneurysm and Arterio-venous Malformation)
- A-23. Sutdy on the Hemodynamics of Apallic Syndrome Using ^131I-MAA
- Acute Epidural Hematoma Caused by Contrecoup Head Injury
- A Female Case of the HCG-Producing Ectopic Pinealoma Associated with Precocious puberty
- Meningioma of the Internal Auditory Canal With Rapidly Progressive Hearing Loss : Case Report
- Vitamin D deficiency in two young adults with biochemical findings resembling pseudohypoparathyroidism type I and type II
- A case of TSH-producing adenoma treated with octreotide in combination with thiamazole for the control of TSH and thyroid hormones after trans-sphenoidal neurosurgery
- Direct Approach to the Ventrolateral Medulla for Cavernous Malformation : Case Report
- Gamma Knife Radiosurgery for Cerebral Arteriovenous Malformations : A Multi-Institutional Study
- Lichen planus-like dermatosis distributed along the lines of Blaschko
- Technical Options for the Surgical Management of Extracranial Carotid Artery Aneurysms : Three Case Reports
- Latent Hypoparathyroidism in an Osteoporotic Patient with Multiple Endocrinopathies and Secondary Hemochromatosis due to Multiple Blood Transfusions, Unmasked by Alendronate and Glucocorticoid at Adrenal Crisis
- Use of propagators in the Hueckel model. VII. Thermochemical and photochemical rearrangement in cycloheptatriene, tropone, and related compounds.
- 45. Relative Shunt Flow in Cerebral Arteriovenous Malformations
- A combination impression technique by Accu-Dent® System broadly extends the surface area of primary casts
- Two Cases of Precocious Puberty Associated with Hypothalamic Hamartoma