Rapid Regrowth of Intracranial Clear Cell Meningioma After Craniotomy and Gamma Knife Radiosurgery
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概要
- 論文の詳細を見る
A 24-year-old woman underwent craniotomy for falx meningioma (5 cm in diameter) on October 24, 1995. The deepest part of the tumor was located in the anterior horn of the lateral ventricle, which was not resected. The histology was clear cell meningioma (CCM), aggressive in nature. The MIB-1 labeling index was high (11%). She underwent gamma knife (GK) radiosurgery for the residual tumor with an irradiation dose of 16 Gy at the tumor periphery on May 24, 1996. The postradiosurgical course was uneventful. The residual intraventricular tumor gradually decreased in size, but the peripheral portion gradually grew into the diencephalic region. The patient remained in good condition for 5 years until September 2001, when she exhibited memory disturbance and lethargy. Magnetic resonance imaging demonstrated a large tumor (4.5 cm in diameter) in the diencephalon, compressing the optic nerves and fornix. The calculated tumor doubling time was 120 days. A second craniotomy was performed on October 9, 2001. The tumor was totally resected through the anterior transcallosal approach. The histology and the MIB-1 labeling index of the tissue from the second operation did not differ markedly from those of the first operation. Neither tumor recurrence nor metastasis has been observed to date. GK radiosurgery contributed to control of the residual intraventricular tumor, but the peripheral portion of the tumor, which received a relatively low radiation dose (16 Gy), grew rapidly. This suggests that a marginal dose of 16 Gy may not be sufficient for control of CCM.
- 日本脳神経外科学会の論文
- 2004-06-15
著者
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TANAKA Noriko
Department of Biostatistics, Harvard School of Public Health
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井出 光信
東京女子医科大学附属第二病院脳神経外科
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YAMAMOTO Masaaki
Department of Neurosurgery, Fukuoka University School of Medicine
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Yamamoto Masaaki
Department Of Neurosurgery Tokyo Women's Medico] University Daini Hospital
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KAWAMURA Hirotsune
Department of Neurological Surgery,Tokyo Women's Medical College
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IDE Mitsunobu
Department of Neurosurgery, Tokyo Women's Medico] University Daini Hospital
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HAGIWARA Shinji
Department of Neurosurgery, Tokyo Women's Medico] University Daini Hospital
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Tanaka Noriko
Department Of Biostatistics Harvard School Of Public Health
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Tanaka Noriko
Department Of Neurosurgery Tokyo Women's Medico] University Daini Hospital
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井出 光信
Department Of Neurosurgery Tokyo Women's Medico] University Daini Hospital
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Tanaka Noriko
Department Of Neurosurgery Tokyo Women's Medical College Dai-ni Hospital
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Hagiwara Shinji
Department Of Neurosurgery Tokyo Women's Medico] University Daini Hospital
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Hagiwara Shinji
Department Of Neurosurgery Tokyo Women's Medical College Dai-ni Hospital
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Hagiwara Shinji
Department Of International Medicine International Center For Medical Research Kobe University Schoo
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Yamamoto Masaaki
Department Of Medicine Institute Of Clinical Endocrinology Tokyo Women's Medical University
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Ide Mitsunobu
Departments Of Neurosurgery Tokyo Women's Medical College Dai-ni Hospital
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Ide Mitsunobu
Department Of Neurosurgery Tokyo Women's Medical College Dai-ni Hospital
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Kawamura Hirotsune
Department Of Neurosurgery Tokyo Women's Medico] University Daini Hospital
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Yamamoto Masaaki
Department Of Dermatology Hyogo College Of Medicine
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Yamamoto Masaaki
Department Of Neurosurgery Neurological Institute Tokyo Women's Medical School
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Yamamoto Masaaki
Department of Chemistry, Faculty of Science, Kanazawa University
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HAGIWARA SHINJI
Department of Environmental Chemistry, Utsunomiya University
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