Insulin Releasing Activity of Gastrointestinal Glucagon-like Immunoreactive Materials in Perfused Rat Pancreas
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概要
- 論文の詳細を見る
Insulin-releasing activity of porcine gastrointestinal glucagon-like immunoreactive materials purified by affinity chromatography was examined in the perfused rat pancreas. When glucose concentration of the perfusate was raised from 60 to 100mg/d<I>l</I>, augmented insulin release was observed. The mean incremental area of immunoreactive insulin (ΣΔIRI) during the first 10min thus observed was 19.07±3.76ng/10min. Pancreatic glucagon and the extract from the gastric fundus showed the enhancement of insulin release in this system when they were added to the perfusate at the rate of 100ng/min for 5min;ΣΔIRI were 41.92±.47 and 71.70±18.09ng/10min, respectively, which were significantly higher than that of 100mg/d<I>l</I> of glucose alone. However, no significant diffrence in the insulinogenic activity was noticed between the extracts from the small intestine and the control.<BR>These results suggest that the extract from the gastric fundus has insulinogenic activity similar to that of pancreatic glucagon.
- 社団法人 日本内分泌学会の論文
著者
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Tanaka Ryoichi
Department Of Botany Faculty Of Science Kyoto University
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Tarui Seiichiro
Second Department Of Internal Medicine Osaka University Medical School
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Kumahara Yuichi
Department Of Medicine And Ceriatrics Oska University Medical School
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SHIMA KENJI
Department of Computers and Systems Engineering, Tokyo Denki University
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MATSUYAMA TATSUO
Second Department of Internal Medicine, Osaka University Medical School
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SAWAZAKI NORIO
Central Laboratory for Clinical Investigation, Osaka University Medical School
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