Half Life of Gastrointestinal Glucagon-like Immunoreactive Materials
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概要
- 論文の詳細を見る
The composition, half life and hyperglycemic action of the porcine gastrointestinal glucagon-like immunoreactive materials were examined. Glucagon immunoreactivity (GI) measured using specific antiglucagon serum was more abundunt in the extract from the gastric fundus than in the one from the small intestine. When the extract from the gastric fundus was injected in dogs, the half life (T1/2) of total glucagonlike immunoreactivity (total GLI) measured using nonspecific antiglucagon serum was 9.5±1.1min (mean±SEM), which was longer than that of crystalline pancreatic glucagon, 3.4±0.2min, but shorter than that of the extract from the small intestine, 15.9±1.3min. On the other hand, T1/2 for GI from the gastric fundus was 5.1±0.9min, which was not significantly different from that of crystalline pancreatic glucagon. Blood sugar levels were significantly increased from the basal by 25±mg/100m<I>l</I> at 10min and 19±4mg/100m<I>l</I> at 15 min following an injection of the extract from the gastric fundus, but such a change in blood sugar levels was not demonstrated when the extract from the small intestine was injected. These results suggest that GI of the gastric fundus is close to pancreatic glucagon in respect of its metabolism and hyperglycemic activity.
- 社団法人 日本内分泌学会の論文
著者
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Kumahara Yuichi
Department of Medicine and Geriatrics, Osaka University Medical School
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Tanaka Ryoichi
Department Of Botany Faculty Of Science Kyoto University
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Tarui Seiichiro
Second Department Of Internal Medicine Osaka University Medical School
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Kumahara Yuichi
Department Of Medicine And Ceriatrics Oska University Medical School
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SHIMA KENJI
Department of Computers and Systems Engineering, Tokyo Denki University
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MATSUYAMA TATSUO
Second Department of Internal Medicine, Osaka University Medical School
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SAWAZAKI NORIO
Central Laboratory for Clinical Investigation, Osaka University Medical School
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Tanaka Ryoichi
Department Of Biomolecular Engineering Graduate School Of Bioscience And Biotechnology Tokyo Institu
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