Glucagon Secretory Responses to Insulin-induced Hypoglycemia and Arginine in Streptozotocin-induced Diabetic Dogs

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概要

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• To clarify whether the reactivity of A cells is regulated by B cell function in the pancreas, plasma glucagon (IRG) responses to insulin-induced hypoglycemia and to arginine infusion were evaluated in streptozotocin (STZ; total 40 mg/kg) treated and control dogs. There was no significant rise in plasma IRG levels during the insulininduced hypoglycemia in the STZ-treated dogs. In contrast, arginine enhanced the IRG secretion from the pancreas to a similar extent in the two groups. This was deduced from the difference between IRG levels in the pancreaticoduodenal and peripheral veins. Neither intravenous glucose nor arginine infusion resulted in a significant rise in plasma insulin (IRI) levels in the STZ-treated dogs. IRI content in the pancreases of STZ-treated dogs was significantly reduced to 5 percent below the levels in the control dogs. The IRG content for control and STZ-treated dogs did not differ. These results indicate that while the responsiveness of A cells to hypoglycemia may depend on the secretory capacity of B cells, such is not the case with arginine.

• 社団法人 日本内分泌学会の論文

著者

• GOTOH MITSUKAZU

  Second Department of Surgery, Osaka University Medical School

• Monden Morito

  Second Department Of Sugery Osaka University Medical School

• SHIMA KENJI

  Department of Computers and Systems Engineering, Tokyo Denki University

• OKAMURA JUN

  Second Department of Surgery, Osaka University Medical School

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