Effect of secretin on plasma insulin and glucagon in man.
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概要
- 論文の詳細を見る
To investigate the effect of physiological doses of secretin on pancreatic A and B cell functions, secretin was infused at a rate of 0.5, 1.0 and 2.0 clinical unit per kg body weight per hr into eight normal men for 30min or 60min after an overnight fast, and changes in plasma immunoreactive insulin (IRI) and glucagon immunoreactivity (GI) were measured while monitoring circulating secretin levels by a radioimmunoassay. During the infusion of secretin, the plasma immunoreactive secretin (IRS) levels rose to 140-390 pg/ml which was within a range of the physiological fluctuation in plasma secretin levels reported hitherto. No significant alteration of plasma IRI and GI levels could be demonstrated during these simulated physiologic infusions of secretin. These data suggest that, in humans, the physiological dose of secretin does not influence insulin and glucagon secretion from the pancreas in the basal state.
- 社団法人 日本内分泌学会の論文
著者
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SHIMA KENJI
Department of Computers and Systems Engineering, Tokyo Denki University
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SAWAZAKI NORIO
Central Laboratory for Clinical Investigation, Osaka University Medical School
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Tanaka Ryoichi
Department Of Biomolecular Engineering Graduate School Of Bioscience And Biotechnology Tokyo Institu
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TANAKA RYOICHI
Department of Medicine and Geriatrics, Osaka University Medical School
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KUROKAWA MASANORI
The second Department of Internal Medicine, Osaka University Medical School
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KUMAHARAI YUICHI
Department of Medicine and Geriatrics, Osaka University Medical School
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