Qualitative Abnormality of Insulin Secretion in a Case with Insulinoma

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概要

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• We have presented here a case of atypical insulinoma. Despite the recurrent episodes of hypoglycemic symptoms, the plasma level of insulin has never been excessive at fasting or by regular provocative tests. Detailed examination had demonstrated qualitative rather than quantitative abnormality of insulin secretion. Hyposuppressibility of insulin secretion by hypoglycemia, borderline diabetic curveof glucose tolerance test, blunted response of insulin to glucagon and leucine were the principal characteristics of these abnormalities. After removal of adenoma, insulin response to glucose, glucagon and leucine was improved. Only secretin provoked a high level of insulin and this abnormal elevation was no longer seen after the removal of adenoma. A removed insulinoma contained 25 U of immunoreactive insulin per gram tissue, but was negative for aldehyde-fuchsin staining. On electronmicroscopy, only atypical β-cell granules were seen.

• 社団法人 日本内分泌学会の論文

著者

• Shichiri Motoaki

  First Department Of Medicine Osaka University Medical

• OKAMURA JUN

  Second Department of Surgery, Osaka University Medical School

• SHIMA KENJI

  Central Laboratory, School of Medicine, Osaka University

• HARANO YUTAKA

  First Department of Medicine, Osaka University Medical School

• KOHAMA MOTOO

  First Department of Medicine, Osaka University Medical School

• ARAKI NOBORU

  First Department of Medicine, Osaka University Medical School

• SAKAMOTO ARITOSHI

  Kansai Rosai Hospital

• HOSHI MITSURU

  First Department of Medicine, Osaka University Medical School

• SHIGETA YUKIKO

  First Department of Medicine, Osaka University Medical School

• SHIMA KENJI

  Central Laboratory for Clinical Investigation and the Second Department of Internal Medicine, Osaka University Medical School

• SHIMA KENJI

  Central Laboratory for Clinical Investigation, Osaka University Medical School

• HARANO YUTAKA

  First Department of Medicine, Osaka Uniuersity Medical school

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• The Effect of Secretin on Glucose-Stimulated Insulin Secretion in Man
• Qualitative Abnormality of Insulin Secretion in a Case with Insulinoma
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