Endocrine Function in a Case of β-Adrenergic Hyperdynamic Circulatory State
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概要
- 論文の詳細を見る
Endocrine functions were investigated in a case of “β-adrenergic hyperdynamic circulatory state”. This state was diagnosed by (1) typical symptoms of cardiac awareness, (2) physical findings (increments of pulse rate and blood pressure by changing positions or walking), (3) increase in cardiac output (5.25<I>l</I>/min→14.03<I>l</I>/min) and decrease in circulatory time (10.8 sec→45.5sec) by isoproterenol infusion (0.02μg/min/kg body weight), (4) rapid loss of symptoms and above findings by propranolol treatment (30mg <I>per os</I> daily) and reappearence by discontinuing medication.<BR>The mechanism of insulin response to glucose has been a controversy as to whether the secretion is transmitted by β-receptor or independent glucose receptor. And in this physiologic β-adrenergic state, it was found that insulin responses in IVGTT and OGTT were within normal limit. When β-adrenergic condition was corrected by propranolol treatment, insulin responses were shown lowered, though in the normal range. This could be reproduced by discontinuing medication. Insulin, glucagon and growth hormone secretions caused by arginine were also found normal, but during the period the patient was on propranolol therapy, all responses were decreased, within the normal range. These results do not positively support the idea that glucose receptor is linked to β-receptor. They do not either agree with the contention that secretions of insulin, glucagon and growth hormone induced by arginine are mediated through β-receptors.
- 社団法人 日本内分泌学会の論文
著者
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Miyata Masaaki
Department Of Cardiovascular Respiratory And Metabolic Medicine Graduate School Of Medicine Kagoshim
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YAMADA TADASHI
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace
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KOBAYASHI YASUO
Department of Dentistry Oral Surgery, Nagano Municipal Hospital
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Tarui Seiichiro
Second Department Of Internal Medicine Osaka University Medical School
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FUSHIMI HISAKO
Department of Medicine, Sumitomo Hospital
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KOYAMA TIAKI
Department of Medicine, Sumitomo Hospital
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MATSUYUKI YOSHIHIKO
Department of Medicine, Sumitomo Hospital
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SUGASE TORU
Health Administration Department, Teishin Hospital
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SHIMA KENJI
Central Laboratory, School of Medicine, Osaka University
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Kobayashi Yasuo
Department Of Anesthesia Asahikawa City Hospital
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Miyata Masaaki
Department Of Cardiovascular Respiratory And Metabolic Medicine Field Of Cardiovascular And Respiratory Disorders Kagoshima University Graduate School Of Medical And Dental Sciences
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TARUI SEIICHIRO
Second Department of Internal Medicine, Osaka University
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SHIMA KENJI
Central Laboratory for Clinical Investigation and the Second Department of Internal Medicine, Osaka University Medical School
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YAMADA TADASHI
Department of Medicine, Sumitomo Hospital
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MIYATA MASAAKI
Department of Medicine, Sumitomo Hospital
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