Calcitonin Induces Hypertrophy and Proliferation of Pars Intermedia Cells of the Rat Pituitary Gland

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概要

• 論文の詳細を見る

• The effects of subcutaneous administration of synthetic salmon calcitonin (sCT) on the pars intermedia (PI) cells of the pituitary gland in the rat were investigated histologically, immunohistochemically, and electron microscopically. Chronic administration of sCT at 0. 75, 7. 5, 30 or 120 IU/kg/day for 4 or 52 weeks to male and female rats induced hypertrophy of PI cells and thickening of the PI without any sign of toxicity. The mean size of PI cells was significantly increased in sCT-treated rats compared to vehicle treated rats, and the magnitude of increase was dose-dependent. sCT treatment of male rats at 120 IU/kg for 3, 7 and 14 days induced 2. 8-, 2. 6-, and 2. 3-fold increase, respectively, in the rate of cell proliferation in the PI estimated by labeling of the nuclei with bromodeoxyuridine. Electron microscopic examination in male rats after sCT treatment at 120 IU/kg for 4 weeks disclosed Golgi complex hypertrophy with electron-dense secretory granules and expansion of rough endoplasmic reticulum. Immunohistochemical staining of the PI for α-melanocyte stimulating hormone and β-endorphin disclosed no marked differences between the control and sCT-treated rats. These results suggest that sCT at pharmacological doses stimulates and increases the thickness of the PI of the rat pituitary gland by increasing the rate of cell proliferation and by inducing hypertrophy of individual cells.

• 社団法人日本動物学会の論文
• 1994-12-15

著者

• KOBAYASHI YASUO

  Department of Dentistry Oral Surgery, Nagano Municipal Hospital

• Horiuchi Toshi

  Safety Resarch Department, Teikoku Hormone Mfg Co., Ltd.

• Suzuki Minoru

  Safety Resarch Department, Teikoku Hormone Mfg Co., Ltd.

• ISOBE Mitsui

  Safety Research Department, Teikoku Hormone Mfg.Co.Ltd.

• Isobe Mitsui

  Safety & Pharmacokinetics Research Department Teikoku Hormone Mfg. Co. Ltd.

• Isobe Mitsui

  Safety Research Department Teikoku Hormone Mfg.co.ltd.

• Horiuchi Toshi

  帝国臓器製薬

• Horiuchi Toshi

  Safety Resarch Department Teikoku Hormone Mfg Co. Ltd.

• Isobe Mitsui

  Safety Research Department Teikoku Hormone Mfg. Co. Ltd.

• Suzuki Minoru

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni

• Suzuki Minoru

  Safety Resarch Department Teikoku Hormone Mfg Co. Ltd.

• Kobayashi Yasuo

  Department Of Applied Biochemistry Hiroshima University

• Suzuki Minoru

  Safety Research Department Teikoku Hormone Mfg.co.ltd.

• Kobayashi Yasuo

  Department Of Anesthesia Asahikawa City Hospital

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