Expression of Glutathione-Peroxidase (GSH-PO) in the Rat Ventral Prostate : Effect of castration and administration of testosterone
スポンサーリンク
概要
- 論文の詳細を見る
Immunolocalization of glutathione-peroxidase (GSH-PO), apoptosis and bcl-2 protein in the rat ventral prostate was investigated in the presence or absence of androgen. Male Sprague-Dawley rats were divided into four experimental groups. Group 1 consisted of intact controls. In group 2, rats were sacrificed two days after castration. In groups 3 and 4, rats were administered subcutaneously 1 mg/animal of testosterone-propionate daily for three or seven days at two days after castration. The intensity of GSH-PO staining in the glandular epithelial cells of the ventral prostate was remarkably decreased after castration (Group 2), and it clearly recovered when testosterone was administered (Groups 3 and 4) to the castrated rats. The prostatic GSH-PO mRNA levels were diminished in the castrated rat ventral prostate but greatly increased by testosterone (Groups 3 and 4). Furthermore, castration (Group 2) induced apoptosis in the prostatic glandular epithelial calls and the apoptosis was reduced by testosterone-administration (Groups 3 and 4) to the castrated rats. In groups 3 and 4, expression of bcl-2 protein was clearly detected in the glandular epithelial cells of the ventral prostate. These findings strongly suggested that expression of GSH-PO and bcl-2 protein in the glandular epithelial cells of the rat ventral prostate is testosterone-dependent.
- 東海大学の論文
著者
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Takekoshi Susumu
Department of Pathology, Tokai University School of Medicine
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Watanabe K
Aoba Gakuen
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Watanabe Keiichi
Department Of Internal Medicine School Of Medicine Tokai University
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Suzuki Minoru
Safety Resarch Department, Teikoku Hormone Mfg Co., Ltd.
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Mikami T
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Tagawa Masashi
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Takekoshi Susumu
Department Of Pathodiagnostics Course Of Basic Clinical Science Tokai University School Of Medicine
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Suzuki Minoru
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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MURAKOSHI Masanori
Safety Research Department, Teikoku Hormone Mfg. Co., Ltd.
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Ikeda Rie
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Murakoshi M
(present Address)products Strategy Dcpartment Pharma Business Strategy Division Teikoku Hormone Mfg.
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Suzuki M
Division Of Material Science Graduate School Of Environmental Earth Science Hokkaido University
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Murakoshi Masanori
Safety Res. Dept. Teikoku Hormone Mfg Co. Ltd.
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Mikami T
Department Of Drug Safety Research Eisai Kawashima Research Laboratories Eisai Co. Ltd.
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Suzuki Minoru
Safety Resarch Department Teikoku Hormone Mfg Co. Ltd.
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Watanabe Katsuto
Department Of Pathology School Of Medicine Tokai University
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Ikada Rie
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Watanabe Keiichi
Department Of Applied Biological Science Faculty Of Agriculture Saga University
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