Exogenous Calcitonin Suppresses Growth Fraction of Thyroid C Cells(Prof. K Watanabe Memorial Article)
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概要
- 論文の詳細を見る
Calcitonin (CT) is a peptide hormone synthesized and secreted by the parafollicular (C) cells of the thyroid. Little is known about the mechanisms controlling proliferation of C cells by other humoral factors including CT, and there is no report that CT suppresses C cell proliferation. The effects of short-term administration of CT on C cell growth fraction were analyzed using BrdU and CT double immunohistochemical method in the rat thyroid. Continuous administration of 0.4 IU/kg and 40 IU/kg synthetic salmon CT for 14 days induced dose-dependent suppression of BrdU labeling number of C cells without decrease of C cell to the total thyroid follicular cell ratio. These results suggest that exogenous CT may induce negative feedback to C cell proliferation in the thyroid.
- 日本組織細胞化学会の論文
著者
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UTSUNOMIYA Hirotoshi
Department of Strategic Surveillance for Functional Food and Comprehensive Traditional Medicine, Wak
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Takekoshi Susumu
Department of Pathology, Tokai University School of Medicine
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KAKUDO Kennichi
Department of 2^ Pathology, Wakayama Medical University
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中村 雅典
東北大学医学部第三解剖学教室
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Suzuma Takaomi
Department Of Pathology Wakayama Medical University
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Nakamura Michihiro
徳島大学 解剖
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Watanabe Keiichi
Department Of Internal Medicine School Of Medicine Tokai University
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Sakurai Takeo
Department Of Pathology Wakayama Medical University
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Sakurai Takeo
和歌山県立医科大学 病理学
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Nakamura Misa
Department of Pathology, Wakayama Medical University
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Mori Ichiro
Department of Pathology, Wakayama Medical University
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Nakamura M
Division Of Immunology And Embryology Department Of Cell Biology Tohoku University School Of Medicin
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Mori Ichiro
Department Of Pathology Wakayama Medical University
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Iteya Iwao
Department of Pathology, Wakayama Medical University
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Nakamura Misa
Department Of Physical Therapy Faculty Of Rehabilitation School Of Rehabilitation Osaka Kawasaki Reh
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Iteya Iwao
Department Of Pathology Wakayama Medical University
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Utsunomiya Hirotoshi
The Department Of Pathology Wakayama Medical University
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Utsunomiya Hirotoshi
Department Of Pathology Tokai University School Of Medicine
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Utsunomiya Hirotoshi
Department Of Pathology School Of Medicine Tokai University
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Nakamura M
Department Of Anatomy And Cell Biology School Of Medicine Tokushima University
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Takekoshi Susumu
Department Of Pathodiagnostics Course Of Basic Clinical Science Tokai University School Of Medicine
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Kakudo Kennichi
Department Of 2^<nd> Pathology Wakayama Medical University
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Kakudo Kennichi
Department Of Pathology Wakayama Medical School
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Kakudo K
Department Of Pathology Wakayama Medical University
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Mori Ichiro
Department Of Cardiovascular Medicine The University Of Tokyo
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Nomura Masahiko
Department Of Physiology Saitama Medical School
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Mori Ichiro
Department Of Human Pathology Wakayama Medical University
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Watanabe Keiichi
Department Of Applied Biological Science Faculty Of Agriculture Saga University
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Utsunomiya Hirotoshi
Department Of Strategic Surveillance For Functional Food And Comprehensive Traditional Medicine Waka
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Mori Ichiro
Department Of Cardiology The University Of Tokyo
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NAKAMURA Misa
Department of Biological Functions and Engineering, Graduate School of Life Science and Systems Engineering, Kyushu Institute of Techonogy
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