Biochemical and Immunohistochemical Analysis of Orotic Acid-induced Fatty Liver
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概要
- 論文の詳細を見る
Orotic acid-induced fatty livers were examined by biochemical and immunohistochemical approaches. Lipid peroxide levels by the thiobarbituric acid method and glutathione-peroxidase (GSH-PO) activity in the liver homogenates from orotic administered rats were similar to those of controls. Immunohistochemical localization of GSH-PO in orotic acid-induced fatty liver was mainly observed in the portal zone of the hepatic lobules. This staining pattern of GSH-PO was similar to that of the controls. No remarkable changes in GSH-PO staining patterns were detected in orotic acid-induced fatty liver. Our data strongly suggested that no lipid peroxidation is actively involved in the genesis of fatty liver due to the administration of orotic acid, and GSH-PO a protective enzyme against lipid peroxidation, was not inhibited by orotic acid-induced fatty liver.
- 東海大学の論文
著者
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Takekoshi Susumu
Department of Pathology, Tokai University School of Medicine
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Watanabe K
Aoba Gakuen
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Watanabe Keiichi
Department Of Internal Medicine School Of Medicine Tokai University
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MURAKOSHI Masanori
Departments of Pathology, School of Medicine, Tokai University
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SUEMIZU Hiroshi
Department of Pathology, Tokai University, School of Medicine
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Takekoshi Susumu
Department Of Pathodiagnostics Course Of Basic Clinical Science Tokai University School Of Medicine
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Murakoshi M
(present Address)products Strategy Dcpartment Pharma Business Strategy Division Teikoku Hormone Mfg.
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Murakoshi Masanori
Department Of Pathology School Of Medicine Tokai University
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MISAWA Mitsuko
Department of Pathology, School of Medicine, Tokai University
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Suemizu Hiroshi
Department Of Pathology Tokai University School Of Medicine
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Misawa Mitsuko
Department Of Pathology School Of Medicine Tokai University
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Watanabe Katsuto
Department Of Pathology School Of Medicine Tokai University
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Watanabe Keiichi
Department Of Applied Biological Science Faculty Of Agriculture Saga University
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