Immunolocalization of Glutathione-Peroxidase (GSH-PO) in the Rat Ventral Prostate : Effects of Castration and Administration of Testosterone
スポンサーリンク
概要
- 論文の詳細を見る
Immunolocalization of glutathione-peroxidase (GSH-PO) in the rat ventral prostate was studied in the presence and absence of androgen. Male Sprague-Dawley rats were diveded into four experimental groups. Group 1 consisted of intact controls. In group 2, rats were sacrificed two days after castration. In groups 3 and 4, rats were injected subcutaneously with 1mg of testosterone-propionate daily, for three or seven days, beginning two days after castration. The intensity of GSH-PO staining in the glandular epithelial cells of the ventral prostate decreased after castration, but recovered following treatment with testosterone. Furthermore, the prostatic GSH-PO mRNA levels were diminished in the castrated rat ventral prostate but greatly increased by testosterone. These findings strongly suggest that the expression of GSH-PO in the glandular epithelial cells of the rat ventral prostate is dependent on testosterone.
- 東海大学の論文
著者
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Takekoshi Susumu
Department of Pathology, Tokai University School of Medicine
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Watanabe K
Aoba Gakuen
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Mikami T
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Tagawa Masashi
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Takekoshi Susumu
Department Of Pathodiagnostics Course Of Basic Clinical Science Tokai University School Of Medicine
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MURAKOSHI Masanori
Safety Research Department, Teikoku Hormone Mfg. Co., Ltd.
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Ikeda Rie
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Murakoshi M
(present Address)products Strategy Dcpartment Pharma Business Strategy Division Teikoku Hormone Mfg.
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Murakoshi Masanori
Safety Res. Dept. Teikoku Hormone Mfg Co. Ltd.
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Mikami T
Department Of Drug Safety Research Eisai Kawashima Research Laboratories Eisai Co. Ltd.
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Watanabe Katsuto
Department Of Pathology School Of Medicine Tokai University
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Ikada Rie
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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