IMMUNOELECTRON MICROSCOPIC INVESTIGATION OF GLUTATHIONE-PEROXIDASE IN THE RAT STOMACH
スポンサーリンク
概要
- 論文の詳細を見る
Immunocytochemical localization of glutathione-peroxidase (GSH-PG) in the stomach was studied in rats under the following experimental conditions; 1) normal untreated 2) histamine-administration 3) atropine-administration in order to clarify the role of GSH-PO. In normal untreated group, GSH-PO was mainly observed in the central part of the gland. At higher magnification, GSH-PO was diffusely distributed in the pyramidal or oval-shaped cytoplasm. Intracellular localization of GSH-PO was predominantly observed in the cytoplasm of the parietal cells. In histamine-administered animal, GSH-PO was intensely stainedin cytoplasm of the parietal cells with well-developed secretory canaliculi. In atropine-administered animal, the intensity of the GSH-PO staining in the parietal cells was remarkably decreased. By immunoelectron microscopic investigations, GSH-PO was noted in cytoplasm as small granules or lysosome-like structures. Based on our data, it is suggested that GSH-PO in the gastric parietal cells may play an important role in the prevention of damage to the microsomes with lipid peroxides induced during the process of HCl secretion. We further speculated that GSH-PO within the lysosome-like structures after atropine-administration might be a result of the degradation process of the peroxidized materials.
- 日本組織細胞化学会の論文
著者
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Watanabe K
Aoba Gakuen
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Suzuki R
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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MURAKOSHI Masanori
Safety Research Department, Teikoku Hormone Mfg. Co., Ltd.
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Murakoshi M
(present Address)products Strategy Dcpartment Pharma Business Strategy Division Teikoku Hormone Mfg.
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Murakoshi Masanori
Safety Res. Dept. Teikoku Hormone Mfg Co. Ltd.
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INADA Rie
Safety Research Department, Teikoku Hormone Mfg. Co., Ltd.,
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SUZUKI R.
Safety Research Department, Teikoku Hormone Mfg, Co. Ltd.
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WATANABE Kei-ichi
Department of Pathology, School of Medicine, Tokai University
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Inada Rie
Safety Res. Dept. Teikoku Hormone Mfg Co. Ltd.
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Watanabe Kei-ichi
Department Of Mathematical Sciences Tokai University
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Inada Rie
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Suzuki R.
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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