Histopathological and Immunocytochemical Studies of Chlormadinone Acetate on the Rat Prostate
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概要
- 論文の詳細を見る
In order to confirm the relationship between glutathione-peroxidase (GSH-PO) and testosterone action in rat ventral prostate, we have studied the immunocytochemical localization of GSH-PO in glandular epithelial cells of rat ventral prostate after chlormadinone acetate CMA) as antiandrogen. In the control rat ventral prostate, GSH-PO was predominantly observed in the glandular epithelial cells and intracellular localization of GSH-PO was exclusively observed in the cytoplasmic matrix near the rough endoplasmic reticulum and it was occasionally noted as small granular structure. In CMA-administered rats, the glandular epithelial cells of the ventral prostate were markedly atrophic. The intensity of GSH-PO staining in the glandular epithelial cells was markedly decreased. Immunoelectron microscopically, GSH-PO-positive granules were hardly seen in the atrophic glandular epithelial cells. These findings strongly suggest that loss of GSH-PO staining in the glandular epithelial cells of the rat ventral prostate treated with CMA as antiandrogen is thought to be caused by inhibition of testosterone action, and that its staining pattern is useful for the effect of antiandrogens or antiprostatic agents on prostate.
- 東海大学の論文
著者
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Mikami T
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Tagawa Masashi
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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MURAKOSHI Masanori
Safety Research Department, Teikoku Hormone Mfg. Co., Ltd.
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Ikeda Rie
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Murakoshi M
(present Address)products Strategy Dcpartment Pharma Business Strategy Division Teikoku Hormone Mfg.
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Murakoshi Masanori
Safety Res. Dept. Teikoku Hormone Mfg Co. Ltd.
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FUKUI Norio
Safety Research Department, Teikoku Hormone Mfg. Co., Ltd.,
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Fukui N
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Fukui Norio
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Mikami T
Department Of Drug Safety Research Eisai Kawashima Research Laboratories Eisai Co. Ltd.
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Inada Rie
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Ikada Rie
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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