Ultrastructural Study in Canine Prostatic Hyperplasia : Effect of Antiandrogen
スポンサーリンク
概要
- 論文の詳細を見る
Ultrastructural changes in canine prostates after treatment with chlormadinone acetate (CMA) were investigated. Old male beagle dogs (5-8 years old) were divided into two experimental groups; group 1 consisted of benign prostatic hyperplasia (BPH) controls, and group 2 received 0.3mg/kg/day CMA orally for 6 months. In group 1 animals, the most striking ultrastructural changes were detected in the rough endoplasmic reticulum (rER) and Golgi complexes. The secretory granules were lined up along the apical plasma membrane, and exocytosis was frequently seen. In group 2 animals, the cytoplasm was electron-lucent and contained relatively few, poorly developed organelles. The rER was sparse and consisted of a few scattered, short profiles studded with ribosomes. The Golgi complexes were inconspicuous. The secretory granules were markedly decreased in both number and size. Furthermore, mitochondrial degeneration such as swollen or disappeared mitochondrial cristae or decreased electron density of the matrix were frequently seen in the smooth muscle cells. Based on our data, atrophy after treatment with CMA may be due to shrinkage of both glandular and stromal compartments in the prostate tissue.
- 東海大学の論文
著者
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Mikami T
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Tagawa Masashi
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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NAKAYAMA Takaharu
Safety Res. Dept., Teikoku Hormone Mfg. Co., Ltd., of Kanagawa Pref.
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MURAKOSHI Masanori
Safety Research Department, Teikoku Hormone Mfg. Co., Ltd.
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Ikeda Rie
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Murakoshi M
(present Address)products Strategy Dcpartment Pharma Business Strategy Division Teikoku Hormone Mfg.
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Mieda Mamoru
Safety Res. And Pharm. Res. Dept. Teikoku Hormone Mfg. Co. Ltd. Of Kanagawa Pref.
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Murakoshi Masanori
Safety Res. Dept. Teikoku Hormone Mfg Co. Ltd.
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Mikami T
Department Of Drug Safety Research Eisai Kawashima Research Laboratories Eisai Co. Ltd.
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Nakayama Takaharu
Medicinal Research Department Teikoku Hormone Mfg. Co. Ltd.
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Nakayama Takaharu
Safety Res. Dept. Teikoku Hormone Mfg. Co. Ltd. Of Kanagawa Pref.
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MASUDA Shuuji
Safety Research Department, Teikoku Hormone Mfg. Co., Ltd.
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HONMA Seijiroh
Pharmacological Research Department, Teikoku Hormone Mfg. Co., Ltd.
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MIEDA Mamoru
Pharmacological Research Department, Teikoku Hormone Mfg. Co., Ltd.
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Masuda Shuuji
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Honma Seijiroh
Safety Res. And Pharm. Res. Dept. Teikoku Hormone Mfg. Co. Ltd. Of Kanagawa Pref.
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Natsume Tsugitaka
Teikoku Hormone Mig. Co. Ltd.
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Ikada Rie
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Nakayama T
Aska Pharmaceutical Co. Ltd. Research & Development Division
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