STUDIES ON EXPERIMENTAL IODINE ALLERGY : 2. IODINATED PROTEIN ANTIGENS AND THEIR GENERATION FROM INORGANIC AND ORGANIC IODINE-CONTAINING CHEMICALS
スポンサーリンク
概要
- 論文の詳細を見る
We hypothesize that iodine allergy is an immune response to iodinated autologous proteins generated in vivo from iodine-containing organic and inorganic chemicals. In this report, effects of protein iodination on elicitogenic activity in guinea pig iodine allergy model and iodinated protein antigen generation in vitro from iodine-containing chemicals were investigated. Active cutaneous anaphylaxis (ACA) and delayed-type hypersensitivity (DTK) tests were performed in guinea pigs immunized with iodine. The amount of iodine (I_2) reacted to proteins for giving them an eliciting activity of ACA was ≥0.15 μmol for 1 mg of albumin. DTH reactions were provoked by intradermal injection of 10^6 PECs reacted with ≥0.075 μmol of I_2. I_2 was generated from a potassium iodide (KI) solution or iodinated contrast media by UV light irradiation. X-ray irradiation of KI and iodinated contrast media in the presence of protein resulted in the generation of iodinated protein antigens. The generation of iodinated protein antigens was inhibited in the presence of reducing agents. Therefore, it is noteworthy that iodine allergy of the present hypothesis is dependent on reactive oxygens. By presenting these ex vivo and in vitro data, we discuss the possibilities for the generation of iodinated protein antigens in vivo.
- 日本トキシコロジー学会の論文
- 2004-05-28
著者
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Sagami Fumio
第一三共安全性研究所
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Sagami Fumio
Drug Safety Research Laboratories Eisai Co. Ltd.
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Sagami Fumio
Subcommittee Of Non-clinical Evaluation Drug Evaluation Committee Japan Pharmaceutical Manufacturers
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Sagami Fumio
Department Of Drug Safety Research Eisai Kawashima Research Laboratories Eisai Co. Ltd.
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Okano K
Eisai Co. Ltd. Ibaraki Jpn
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Okano Kazuo
Exploratory Division Eisai Tsukuba Research Laboratories Eisai Co. Ltd.
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Okano Kazuo
Department Of Electrical System Engineering Polytechnic University
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Mikami T
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Tagawa Masashi
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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SUGIHARA Yoshiki
Department of Drug Safety Research, Eisai Tsukuba Research Laboratories, Eisai Co., Ltd.
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SHIONOYA Hiroshi
Department of Drug Safety Research, Eisai Kawashima Research Laboratories, Eisai Co., Ltd.
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MIKAMI Takashi
Department of Drug Safety Research, Eisai Kawashima Research Laboratories, Eisai Co., Ltd.
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KATAYAMA Kouichi
Exploratory Division, Eisai Tsukuba Research Laboratories, Eisai Co., Ltd.
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Mikami T
Department Of Drug Safety Research Eisai Kawashima Research Laboratories Eisai Co. Ltd.
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Sagami Fumio
Department Of Developmental Safety Assessment Research Eisai Co. Ltd.
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Sugihara Yoshiki
Department Of Drug Safety Research Eisai Tsukuba Research Laboratories Eisai Co. Ltd.
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Katayama Kouichi
Exploratory Division Eisai Tsukuba Research Laboratories Eisai Co. Ltd.
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Mikami Takashi
Department Of Applied Chemistry Graduate School Of Advanced Science And Engineering Waseda Universit
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Shionoya H
Department Of Drug Safety Research Eisai Kawashima Research Laboratories Eisai Co. Ltd.
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