COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 17)TESTICULAR TOXICITY OF E7010, A SULFONAMIDE TUBULIN POLYMERIZATION INHIBITOR
スポンサーリンク
概要
- 論文の詳細を見る
E7010 (N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide), a sulfonamide antitumor agent that inhibits tubulin polymerization, was orally administered to male Slc:SD rats at doses of 50 and 75 mg/kg once a day for 2 weeks. E7010 at a dose of 75 mg/kg induced severe testicular lesions characterized by marked decrease and/or loss of seminiferous epithelial cells, which sometimes resulted in tubules with only Sertoli cells. In the 50 mg/kg group, alteration of germ cells was evident at various stages of spermatogenesis, and apoptotic figures of meiotic spermatocytes at stage XIV were frequently observed. Single dose treatment of 50 mg/kg was also performed and was revealed a decrease of round spermatids in stage VII at necropsy after 1 week. Thus the target cells were considered to be meiotic spermatocytes at stage XIV. The present study indicates that 2-weeks repeated dosing is sufficient to detect the testicular toxicity of E7010.
- 日本トキシコロジー学会の論文
- 2000-10-25
著者
-
早川 和宏
Drug Safety & Disposition Research Laboratories Eisai Co. Ltd.
-
今井 敏夫
Drug Safety & Disposition Research Laboratories Eisai Co. Ltd.
-
Sagami Fumio
第一三共安全性研究所
-
Sagami Fumio
Drug Safety Research Laboratories Eisai Co. Ltd.
-
Sagami Fumio
Subcommittee Of Non-clinical Evaluation Drug Evaluation Committee Japan Pharmaceutical Manufacturers
-
Sagami Fumio
Department Of Drug Safety Research Eisai Kawashima Research Laboratories Eisai Co. Ltd.
-
Sato Kunio
Drug Safety & Disposition Research Laboratories Eisai Co. Ltd.
-
TASHIRO Toshifumi
Drug Safety Research and Development, Nagoya Laboratories, Pfizer Global Research and Development, P
-
田代 俊文
Drug Safety & Disposition Research Laboratories Eisai Co. Ltd.
-
Tashiro Toshifumi
Drug Safety Research And Development Nagoya Laboratories Pfizer Global Research And Development Pfiz
-
細川 暁
Drug Safety & Disposition Research Laboratories Eisai Co. Ltd.
-
Sato K
Drug Safety & Disposition Research Laboratories Eisai Co. Ltd.
-
Imai T
Laboratory Of Pathology Aichi Cancer Center Research Institute
-
HOSOKAWA Satoru
Drug Safety Research Lab., Eisai Co., Ltd.
-
Hosokawa S
Drug Safety & Disposition Research Laboratories Eisai Co. Ltd.
-
Hosokawa Shunji
Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
-
HAYAKAWA Kazuhiro
Drug Safety & Disposition Research Laboratories, Eisai Co., Ltd.
-
KATSURAYAMA Tomiharu
Drug Safety & Disposition Research Laboratories, Eisai Co., Ltd.
-
IMAI Toshio
Drug Safety & Disposition Research Laboratories, Eisai Co., Ltd.
-
Hosokawa Satoru
Drug Safety And Disposition
-
Sagami Fumio
Drug Safety Research Laboratories Eisai Co. Ltb.
-
Katsurayama Tomiharu
Drug Safety & Disposition Research Laboratories Eisai Co. Ltd.
-
Tashiro Toshifumi
Drug Safety & Disposition Research Laboratories, Eisai Co., Ltd.
関連論文
- The predictivity of preliminary embryo-fetal development (EFD) studies : results of a retrospective survey in Japanese pharmaceutical companies
- P6-38 Relationship between hepatic enzyme induction and carcinogenicity in the p53 deficient mice treated with aminophenylnorharman(DRUG METABOLISM/CARCINOGENICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Detection of Initiating and Promoting Activity of Aminophenylnorharman with a Five-week In Vivo Initiation Assay
- Tissue-dependent susceptibility of p53 knockout mice to chemical-induced carcinogenesis (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Tongue Carcinogenic Susceptibility of p53 Deficient Mice to Methyl-n-amylnitrosamine
- Appearance of Osteonectin-expressing Fibroblastic Cells in Early Rat Stomach Carcinogenesis and Stomach Tumors Induced with N-Methyl-N'-nitro-N-nitrosoguanidine
- The Effects of Allyl Alcohol-induced Cell Proliferation for Detection of Initiation Activities of Chemicals in Rat Liver
- Differential Effects of Partial Hepatectomy and Carbon Tetrachloride Administration on Induction of Liver Cell Foci in a Model for Detection of Initiation Activity
- Stable Expression of Glutathione S-transferase P-form mRNA and TGF-α Immunohistochemical Expression are Useful Markers for Identification of Persistent Nodules from an Early Stage in Rat Hepatocarcinogenesis
- Sparse Distribution of Hepatocyte Growth Factor-producing Cells inside Hepatocellular Foci in Rats Treated with Hepatocarcinogens
- Rare Occurrence of ras and p53 Gene Mutations in Mouse Stomach Tumors Induced by N-Methyl-N-nitrosourea
- Dose-dependent Induction of Both Pepsinogen-altered Pyloric Glands and Adenocarcinomas in the Glandular Stomach of C3H Mice Treated with N-Methyl-N-nitrosourea
- Collaborative work on evaluation of ovarian toxicity by repeated-dose and fertility studies in female rats
- Proteomic analysis for neuronal vacuolation induced by MK-801 in rat retrosplenial cortex
- ADVANTAGES OF TRIPLE THERAPY WITH MIZORIBINE, CYCLOSPORINE AND PREDNISOLONE OVER OTHER TYPES OF TRIPLE AND/OR DOUBLE THERAPY INCLUDING CYCLOSPORINE FOR RENAL TRANSPLANTATION
- Safety assessment of biopharmaceuticals : Japanese perspective on ICH S6 guideline maintenance
- Points to consider on the non-clinical safety evaluation of anticancer drugs
- CURRENT OPINION : SAFETY EVALUATION OF DRUG METABOLITES IN DEVELOPMENT OF PHARMACEUTICALS
- "POINTS TO CONSIDER" REGARDING SAFETY ASSESSMENT OF BIOTECHNOLOGY-DERIVED PHARMACEUTICALS IN NON-CLINICAL STUDIES (ENGLISH TRANSLATION)
- Current status of pharmaceutical industries in Japan on pharmacogenomics and toxicogenomics in 2005(Toxicogenomics, Toxicoproteomics, Proceedings of the 32nd Annual Meeting)
- S3-6 Problems and Meanings of Genome-based Drug Discovery in Japanese Pharmaceutical Companies(SYMPOSIUM 3: BENEFITS OF PHARMACOGENOMICS/PHARMACOGENETICS IN PHARMACEUTICAL DEVELOPMENT)(Proceedings of the 31st Annual Meeting)
- Erythroderma and Epidermal Necrosis Induced by a Type of Proton Pump Inhibitor in Beagle Dogs
- P7-39 Current Analysis and Prospects of New Toxicological Biomarker : Biomarkers of Hepatotoxicity(GENERAL TOXICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P7-38 Current analysis and prospects of new toxicological biomarker : biomarkers of cardiotoxicity(GENERAL TOXICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P7-37 Current Analysis and Prospects of New Toxicological Biomarker : Biomarkers of Nephrotoxicity(GENERAL TOXICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- S13-1 Current analysis and prospects of new toxicological biomarkers : with central focus on heart, liver and kidney(SYMPOSIUM 13: CURRENT STATUS AND FUTURE ASPECTS OF NEW TOXICOLOGICALLY RESPONSIBLE BIOMARKERS)(Proceedings of the 31st Annual Meeting)
- STUDIES ON EXPERIMENTAL IODINE ALLERGY : 3. LOW MOLECULAR WEIGHT ELICITOGENIC ANTIGENS OF IODINE ALLERGY
- STUDIES ON EXPERIMENTAL IODINE ALLERGY : 2. IODINATED PROTEIN ANTIGENS AND THEIR GENERATION FROM INORGANIC AND ORGANIC IODINE-CONTAINING CHEMICALS
- STUDIES ON EXPERIMENTAL IODINE ALLERGY : 1. ANTIGEN RECOGNITION OF GUINEA PIG ANTI-IODINE ANTIBODY
- 3A-15 Changes in gerteral toxicologecal parameters in hyperprolactinemic rats
- P6-44 The effects of chronic dietary restriction on biological characteristics in Crj:CD(SD)IGS rats(DRUG METABOLISM/CARCINOGENICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Collaborative work on evaluation of ovarian toxicity : 11) Two- or four-week repeated-dose studies and fertility study of ethylene glycol monomethyl ether in female rats
- P-11 Application of hepatocytes cultured in a sandwich configuration to toxicity assessment.(Proceedings of the 27th Annual Meeting)
- P8-43 Study on the difference of CK activity between plasma and serum in monkey(BLOOD/TOXICOKINETICS/OTHERS-2)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Paracortical hyperplasia of superficial lymph nodes in a new mutant strain of hairless rats (ISh) : A lesion similar to human dermatopathic lymphadenopathy
- Expression of osteonectin in rat stomach pyloric mucosa after N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) exposure
- Mechanism for benzothiazole derivative-induced hepatotoxicity in rats(SYMPOSIUM 1 : MECHANISMS OF HEPATOTOXIC EFFECTS)
- P-90 Collaborative Work to Evaluate Toxicity on Male Reproductive Organs with 2 Weeks Repeated Daily Dosing in Rats : Testicular Toxicity of E7010, A Sulfonamide Tubulin Polymerlzation Inhibitor(Proceedings of the 27th Annual Meeting)
- COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 17)TESTICULAR TOXICITY OF E7010, A SULFONAMIDE TUBULIN POLYMERIZATION INHIBITOR
- TOXICOLOGICAL RESPONSE OF RATS TO A NOVEL MONOAMINE OXIDASE TYPE-A INHIBITOR, (5R)-3-[2-((1S)-3-CYANO-1-HYDROX-YPROPYL)BENZOTHIAZOL-6-YL]-5-METHOXYMETHYL-2-OXAZOLIDI-NONE (E2011), ORALLY ADMINISTERED FOR 13 WEEKS
- "B-5 Modification of Drug Conjugation Pathway by Repeated Administration of Conjugating Enzyme Inhibitors in Rats.
- MORPHOLOGIC AND MORPHOMETRIC ANALYSIS OF CELLULAR AND SUBCELLULAR STRUCTURES OF RAT GASTRIC MUCOSA AFTER ADMINISTRATION OF E3810, A NOVEL PROTON PUMP INHIBITOR
- 21C-02-4 Hepatic Drug Metabolizing Enzymes in CB6F1-TgrasH2 Mice.
- HORMONAL INVESTIGATIONS OF A POSSIBLE MECHANISM FOR THE ELEVATION OF SERUM LUTEINIZING HORMONE LEVELS IN MALE RATS BY OXOLINIC ACID.
- HORMONAL DISREGULATION MECHANISM IN THE RAT THYROID TUMOR INDUCED BY DINICONAZOLE
- EFFECTS OF DIETHOFENCARB ON THYROID FUNCTION AND HEPATIC UDP-GLUCURONYLTRANSFERASE ACTIVITY IN RATS
- TOXICOKINETICS:ITS SIGNIFICANCE AND PRACTICAL PROBLEMS
- EFFECTS OF PROCYMIDONE ON REPRODUCTIVE ORGANS AND SERUM GONADOTROPINS IN MALE RATS
- THE AFFINITY OF PROCYMIDONE TO ANDROGEN RECEPTOR IN RATS AND MICE
- "P-2 Chronic effects of amurubicin on cardiac functions in dogs.
- Proteomic analysis for neuronal vacuolation induced by MK-801 in rat retrosplenial cortex
- P-060 Dextran sulfate sodiumマウス大腸炎モデルにおけるBenzo[a]pyreneによる大腸腫瘍の発生(ポスターセッション)
- DETERMINATION OF THE TIME AT WHICH CONGENITAL HYDROCEPHALUS IS INDUCED WITH HIGHER INCIDENCE DURING THE EARLY GESTATIONAL PERIOD IN RATS
- MANUAL METHOD FOR QUALITATIVE AND QUANTITATIVE ASSESSMENT OF MALE REPRODUCTIVE EFFECTS IN RATS
- P-103 大腸非発癌・変異原物質であるベンゾ[a]ピレンは大腸炎症誘発物質であるDSS後処理によって大腸癌を誘発する(VII.遺伝毒性試験法(II),ポスターセッション)
- P-104(O-2) ベンゾ[a]ピレンとデキストラン硫酸ナトリウム(DSS)を用いたマウス短期大腸発がんモデルにおける網羅的遺伝子発現解析 : 腫瘍発生との関連が示唆される5個の候補遺伝子の抽出(VII.遺伝毒性試験法(II),ポスターセッション)