ADVANTAGES OF TRIPLE THERAPY WITH MIZORIBINE, CYCLOSPORINE AND PREDNISOLONE OVER OTHER TYPES OF TRIPLE AND/OR DOUBLE THERAPY INCLUDING CYCLOSPORINE FOR RENAL TRANSPLANTATION

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概要

• 論文の詳細を見る

• Mizoribine (Mz) is an analogue of azathioprine (Az) with less hepatotoxicity, being extensively used as immunosuppressant in place of the latter agent especially in Japan. However, careful comparative studies of mizoribine (Mz), cyclosporine (Cy), and prednisolone (Pr) versus azathioprine (Az), Cy and Pr or Cy and Pr in renal allotranspalnt patients have not been reported. Retrospectively we compared triple therapy with Mz, Cy, and Pr (group I, n=50) to triple therapy with Az, Cy and Pr (group II, n=13) and/or double therapy with Cy and Pr (group III, n=11) in one-haplotype-identical living related renal transplantations performed between Oct. 1984 through March 1989. Initial and maintenance doses of Cy in groups I and II were largely two thirds of those in group III. Patient and graft survival rates at 3 years in each group are 100% and 92% (group I), 100% and 91% (group II), and 91% and 82% (group III). There were no statistical differences in patient and graft survival rates between these three groups. The incidences of miscellaneous complications were the same in the groups. Bone marrow suppression, however, was significantly less in group I than in group II (P<0.005). Cy related nephrotoxicity was apparently less in groups I and II than in group III. Estimated US $5,000 in a year can be saved by immunosuppressive treatment in a patient of group I as compared to a patient in group III. Therefore, we conclude that triple therapy with Mz, Cy and Pr is superior to those with Az, Cy and Pr, and/or double therapy with Cy and Pr.

• 日本トキシコロジー学会の論文
• 1991-11-25

著者

• NAGAO Takeshi

  Department of Fifth Surgery, Hachioji Medical Center, Tokyo Medical University

• Nagao Takeshi

  Department Of Transplantation Hachioji Medical Center Tokyo Medical College

• ISHIDA Yuichi

  Department of Oral & Maxillofacial Prosthodontics and Oral Implantology, The University of Tokushima

• WATANABE Kenji

  Department of Kampo Medicine, Keio University, School of Medicine

• TOMIKAWA Shinji

  Department of Organ Transplantation and Surgery,Institute of Medical Science,University of Tokyo

• UCHIDA Hisanori

  Department of Surgery,Kitatama Hospital

• INOUE Sumio

  Department of Surgery and Organ Transplantation, Institute of Medical Science

• MITA Kunshi

  Departments of Surgery and Organ Transplantation, Institute of Medical Science, University of Tokyo

• BEKKU Yoshibumi

  Departments of Surgery and Organ Transplantation, Institute of Medical Science, University of Tokyo

• NISHIMURA Youji

  Departments of Surgery and Organ Transplantation, Institute of Medical Science, University of Tokyo

• SUGIMOTO Hisayuki

  Departments of Surgery and Organ Transplantation, Institute of Medical Science, University of Tokyo

• OSAKABE Tsuneo

  Departments of Surgery, Kitasato University

• NAKAYAMA Yoshisuke

  Departments of Surgery, Kitasato University

• YOKOTA Kazuo

  Departments of Surgery, Kitasato University

• SATO Koushi

  Departments of Surgery, Kitasato University

• ENDO Tadao

  Departments of Urology, Kitasato University

• OKUBO Mitsuhito

  Departments of Internal Medicine, Kitasato University

• Bekku Yoshibumi

  Department Of Organ Transplantation And Surgery Institute Of Medical Science University Of Tokyo

• Sato Kunio

  Drug Safety & Disposition Research Laboratories Eisai Co. Ltd.

• Nishimura Youji

  Department Of Organ Transplantation And Surgery Institute Of Medical Science University Of Tokyo

• Tomikawa Shinji

  Department Of Organ Transplantation And Surgery Institute Of Medical Science University Of Tokyo

• Endo Tadao

  Department Of Electronics & Communication School Of Engineering Meiji University

• Endo Tadao

  Departments Of Urology Kitasato University

• Sato K

  Drug Safety & Disposition Research Laboratories Eisai Co. Ltd.

• Inoue Sumio

  Department Of Surgery And Organ Transplantation Institute Of Medical Science

• Mita Kunshi

  Department Of Organ Transplantation And Surgery Institute Of Medical Science University Of Tokyo

• Yokota Kazuo

  Departments Of Surgery Kitasato University

• Ishida Yuichi

  Department Of Surgery And Organ Transplantation Institute Of Medical Science

• Osakabe Tsuneo

  Departments Of Surgery Kitasato University

• Okubo Mitsuhito

  Departments Of Internal Medicine Kitasato University

• Uchida Hisanori

  Department Of Surgery Kitatama Hospital

• Uchida Hisanori

  Department Of Medicine Department Of Surgery Kitasato University School Of Medicine

• Watanabe Kenji

  Department Of Organ Transplantation And Surgery Institute Of Medical Science University Of Tokyo

• Sugimoto Hisayuki

  Departments Of Surgery And Organ Transplantation Institute Of Medical Science University Of Tokyo

• Nakayama Yoshisuke

  Department Of Chemistry Faculty Of Science Nagoya University

• Nakayama Yoshisuke

  Departments Of Surgery Kitasato University

• Watanabe Kenji

  Department Of Gastroenterology Osaka City University Graduate School Of Medicine

• Watanabe Kenji

  Department Of Anatomy Fukui Medical School

• Watanabe Kenji

  Department Of Agricultural Chemistry College Of Agriculture And Veterinary Medicine Nihon University

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