Proteomic analysis for neuronal vacuolation induced by MK-801 in rat retrosplenial cortex
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概要
- 論文の詳細を見る
Proteomic analysis was carried out for neuronal vacuolation in rat retrosplenial cortex (RSC) induced by MK-801, a N-methyl-D-aspartate (NMDA) receptor antagonist. Female rats were given a single subcutaneous (sc) injection of either MK-801 (9 mg/kg in saline) or saline. Comparison of changes in proteins in the RSC region between MK-801- and saline-treated groups revealed that MK-801 induced changes in six proteins involved in vesicular transport (vesicle-fusing ATPase) and glycolysis (fructose-bisphosphate aldolase C, triosephosphate isomerase, and glyceraldehyde-3-phosphate dehydrogenase).
著者
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AOKI Toyohiko
Drug Safety Research Laboratories, Eisai Co., Ltd.
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HOSOKAWA Satoru
Drug Safety Research Lab., Eisai Co., Ltd.
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Shiotani Motohiro
Drug Safety Japan, Global Drug Safety, Biopharmaceutical Assessments Core Function Unit, Eisai Produ
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Nakano Kyoko
Drug Safety Japan, Global Drug Safety, Biopharmaceutical Assessments Core Function Unit, Eisai Produ
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Yamauchi Emiko
Biomarkers and Personalized Medicine Core Function Unit, Eisai Product Creation Systems
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Oda Yoshiya
Biomarkers and Personalized Medicine Core Function Unit, Eisai Product Creation Systems
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