Proteomic analysis for neuronal vacuolation induced by MK-801 in rat retrosplenial cortex
スポンサーリンク
概要
- 論文の詳細を見る
Proteomic analysis was carried out for neuronal vacuolation in rat retrosplenial cortex (RSC) induced by MK-801, a N-methyl-D-aspartate (NMDA) receptor antagonist. Female rats were given a single subcutaneous (sc) injection of either MK-801 (9 mg/kg in saline) or saline. Comparison of changes in proteins in the RSC region between MK-801- and saline-treated groups revealed that MK-801 induced changes in six proteins involved in vesicular transport (vesicle-fusing ATPase) and glycolysis (fructose-bisphosphate aldolase C, triosephosphate isomerase, and glyceraldehyde-3-phosphate dehydrogenase).
- 2011-02-01
著者
-
AOKI Toyohiko
Drug Safety Research Laboratories, Eisai Co., Ltd.
-
HOSOKAWA Satoru
Drug Safety Research Lab., Eisai Co., Ltd.
-
Shiotani Motohiro
Drug Safety Japan, Global Drug Safety, Biopharmaceutical Assessments Core Function Unit, Eisai Produ
-
Nakano Kyoko
Drug Safety Japan, Global Drug Safety, Biopharmaceutical Assessments Core Function Unit, Eisai Produ
-
Yamauchi Emiko
Biomarkers and Personalized Medicine Core Function Unit, Eisai Product Creation Systems
-
Oda Yoshiya
Biomarkers and Personalized Medicine Core Function Unit, Eisai Product Creation Systems
-
Hosokawa Satoru
Drug Safety And Disposition
-
Aoki Toyohiko
Drug Safety Japan Global Drug Safety Biopharmaceutical Assessments Core Function Unit
-
Nakano Kyoko
Drug Safety Japan Global Drug Safety Biopharmaceutical Assessments Core Function Unit
-
Oda Yoshiya
Biomarkers And Personalized Medicine Core Function Unit
-
Hosokawa Satoru
Drug Safety Japan Global Drug Safety Biopharmaceutical Assessments Core Function Unit
-
Yamauchi Emiko
Biomarkers And Personalized Medicine Core Function Unit
-
Shiotani Motohiro
Drug Safety Japan Global Drug Safety Biopharmaceutical Assessments Core Function Unit
-
Oda Yoshiya
Biomarker & Personalized Medicine, Eisai Product Creation Systems
関連論文
- Current Status of Carcinogenicity Assessment of Peroxisome Proliferator-Activated Receptor Agonists by the US FDA and a Mode-of-Action Approach to the Carcinogenic Potential
- Proteomic analysis for neuronal vacuolation induced by MK-801 in rat retrosplenial cortex
- A Comparision of the Results of Rat and Mouse Carcinogenicity Studies Conducted on Pharmaceuticals
- P6-44 The effects of chronic dietary restriction on biological characteristics in Crj:CD(SD)IGS rats(DRUG METABOLISM/CARCINOGENICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Collaborative work on evaluation of ovarian toxicity : 11) Two- or four-week repeated-dose studies and fertility study of ethylene glycol monomethyl ether in female rats
- P8-43 Study on the difference of CK activity between plasma and serum in monkey(BLOOD/TOXICOKINETICS/OTHERS-2)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Paracortical hyperplasia of superficial lymph nodes in a new mutant strain of hairless rats (ISh) : A lesion similar to human dermatopathic lymphadenopathy
- Mechanism for benzothiazole derivative-induced hepatotoxicity in rats(SYMPOSIUM 1 : MECHANISMS OF HEPATOTOXIC EFFECTS)
- P-90 Collaborative Work to Evaluate Toxicity on Male Reproductive Organs with 2 Weeks Repeated Daily Dosing in Rats : Testicular Toxicity of E7010, A Sulfonamide Tubulin Polymerlzation Inhibitor(Proceedings of the 27th Annual Meeting)
- COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 17)TESTICULAR TOXICITY OF E7010, A SULFONAMIDE TUBULIN POLYMERIZATION INHIBITOR
- TOXICOLOGICAL RESPONSE OF RATS TO A NOVEL MONOAMINE OXIDASE TYPE-A INHIBITOR, (5R)-3-[2-((1S)-3-CYANO-1-HYDROX-YPROPYL)BENZOTHIAZOL-6-YL]-5-METHOXYMETHYL-2-OXAZOLIDI-NONE (E2011), ORALLY ADMINISTERED FOR 13 WEEKS
- Report 4 : CASE STUDY OF CARCINOGENICITY BY INITIATION-PROMOTION MODEL (CARCINOGENlClTY STUDIES)
- Proteomic analysis for neuronal vacuolation induced by MK-801 in rat retrosplenial cortex
- ^1H-NMR Based Metabonomics Study of Galactosamine, Methylene Dianiline, and Clofibrate in Rats(Liver, Alimentary system, Proceedings of the 32nd Annual Meeting)
- P6-57 NMR spectroscopic analysis of rat urine samples after D-galactosamine or 4-aminophenol administration(TOXICOGENOMICS)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Peptide Peak Detection for Low Resolution MALDI-TOF Mass Spectrometry