Report 4 : CASE STUDY OF CARCINOGENICITY BY INITIATION-PROMOTION MODEL (<Session 4>CARCINOGENlClTY STUDIES)
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概要
- 論文の詳細を見る
- 日本トキシコロジー学会の論文
- 1996-12-20
著者
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MUTAI Mamoru
Toxicology Laboratory, Life Science Research Sector, Mitsubishi Chemical Co. Yokohama Research Cente
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Mutai M
Safety Research Laboratory (kazusa) Mitsubishi Tanabe Pharma Corporation
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AOKI Toyohiko
Drug Safety Research Laboratories, Eisai Co., Ltd.
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Mutai Mamoru
First Department Of Pathology Nagoya City University Medical School
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Mutai Mamoru
Toxicol.lab.life Sci.res.sect.mitsubishi Chemical Co. Ltd.
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Aoki Toyohiko
Drug Safety Research Laboratories Eisai Co. Ltd.
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Mutai Mamoru
Safety Research Laboratory (kazusa) Mitsubishi Tanabe Pharma Corporation
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Aoki Toyohiko
Drug Safety Japan Global Drug Safety Biopharmaceutical Assessments Core Function Unit
関連論文
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- Close Relation of Transforming Growth Factor-α Positive Hepatic Foci to Hepatocellular Tumor Development in the Rat
- Dose-related changes in gene expression in the livers of rats treated with sodium Phenobarbital as assessed using a three-dimensional microarray system. (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30t
- Transforming growth factor β derived from bone matrix promotes cell proliferation of prostate cancer and osteoclast activation-associated osteolysis in the bone microenvironment
- Prediction of carcinogenic potential by a toxicogenomic approach using rat hepatoma cells
- Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by leuprorelin, a luteinizing hormone-releasing hormone agonist
- Limited Effects of Disrupted Gap Junctions in the Liver on Multi-organ Carcinogenesis Induced by Diisopropanolnitrosamine in the Mutant Connexin 32 Transgenic Rat
- Downregulation of apoptosis revealed by laser microdissection and cDNA microarray analysis of related genes in rat liver preneoplastic lesions
- Inhibition of cell proliferation by nobiletin, a dietary phytochemical, associated with apoptosis and characteristic gene expression, but lack of effect on early rat hepatocarcinogenesis in vivo
- P8-29 The left lobe model as an improved mouse pulmonary fibrosis model by intratracheal bleomycin administration(STATISTICAL AND TEST METHODS/LOCAL STIMURATION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- B31 DETECTION OF HEPATOCARCINOGENIC POTENTIAL OF 5 CHEMICALS BY A MEDIUM-TERM BIOASSAY SYSTEM
- Current Status of Carcinogenicity Assessment of Peroxisome Proliferator-Activated Receptor Agonists by the US FDA and a Mode-of-Action Approach to the Carcinogenic Potential
- Proteomic analysis for neuronal vacuolation induced by MK-801 in rat retrosplenial cortex
- OPTIMIZATION OF AN ANIMAL TEST PROTOCOL FOR TOXICOGENOMICS STUDIES (II); A CROSS-LABORATORY GENE EXPRESSION ANALYSIS
- OPTIMIZATION OF AN ANIMAL TEST PROTOCOL FOR TOXICOGENOMICS STUDIES (I); REQUIREMENT STUDY OF A PROTOCOL
- MECHANISTIC STUDY ON INHIBITION OF SERUM THYROID HORMONE PRODUCTION BY THIOUREA
- Transgenic Rats Carrying Human c-Ha-ras Proto-oncogene Are Highly Susceptible to N-Nitorosomethylbenzylamine Induction of Esphageal Tumorigenesis
- Harman and Norharman Suppressed but NaNO_2 Enhanced the Development of Preneoplastic Liver Cell Foci in 2-Amino-3,8-Dimethylimidazo[4,5-f]Quinoxaline (MeIQx)-Treated Rats
- Preferential mammary carcinogenic effects of 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine (PhIP) in human c-Ha-ras proto-oncogene transgenic rats
- Possible Chemopreventive Effects of Bovine Lactoferrin on Esophagus and Lung Carcinogenesis in the Rat
- Differential Dose-dependent Effects of α-, β-Carotenes and Lycopene on Gap-junctional Intercellular Communication in Rat Liver in vivo
- Inhibition of Azoxymethane-initiated Colon Tumor by Bovine Lactoferrin Administration in F344 Rats
- Triazine Derivatives Inhibit Rat Hepatocarcinogenesis but Do Not Enhance Gap Junctional Intercellular Communication
- Modifying Influence of Swine Serum-induced Liver Fibrosis on Development of Preneoplastic Lesions in Rat Liver
- Lack of effect of human c-Ha-ras proto-oncogene overexpression on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats
- Survey of Carcinogenicity Studies of the Pharmaceuticals in Rodents
- A Comparision of the Results of Rat and Mouse Carcinogenicity Studies Conducted on Pharmaceuticals
- 22A-10-3 Detection of Dibromoacetic acid-induced histopathological changes in testes and epididymides of rats by 2-weeks repeated dose toxicity study.
- 21C-10-2 Detection of carcinogenic potential of Diethylstibestrol (DES) and N-methyl-N-nitrosourea (MNU) by the alternative testing model using Tg-rasH2 mouse
- A Transgenic Rat Model of Prostate Carcinogenesis
- Collaborative work on evaluation of ovarian toxicity : 17) Two- or four-week repeated-dose studies and fertility study of sulpiride in female rats
- Effect of dosing interval between edaravone and cefalotin/glycerol on the nephrotoxicity in rats(Kidney, Urinary system, Proceedings of the 32nd Annual Meeting)
- P7-14 Renal Toxicity of Furosemide in Rats : Effects of Water-Deprived Condition or Coadministration of Cefalotin and Glycerol(IMMUNE AND ALLERGIC SYSTEM/KIDNEYS AND URINARY EXCRETION SYSTEM/CYTOTOXICITY/OTHERS-1)(GENERAL SESSION BY POSTER PRESENTATION)(P
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- 90-day repeated dose toxicity study of gum arabic(General toxicity, Proceedings of the 32nd Annual Meeting)
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- Age-dependent histopathological findings in the prostate of probasin/SV40 T antigen transgenic rats : Lack of influence of carcinogen or testosterone treatment
- P11-09 Glucose Alters the Susceptibility of Mesangial Cells to Contrast Media.
- Species differences between rats and dogs in LPS-stimulated Kupffer cells and monocytes.(GENERAL SESSION BY POSTER PRESENTATION)(LIVER AND DIGESTIVE SYSTEM)
- KUPFFER CELL- MEDIATED CYTOTOXICITY INDUCED BY LIPOPOLYSACCHARIDE0111:B4 IS GREATER IN DOGS THAN IN RATS AND MONKEYS
- PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR α(PPARα)AGONIST, WY-14, 643, INCREASED TRANSCRIPTION OF MYOSIN LIGHT CHAIN-2 IN CARDIOMYOCYTES
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- Metabonomic analysis of rat urine following single dose of α-naphthylisothiocyanate (ANIT) or puromycin aminonucleoside (PAN) (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
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- ORIGIN OF SERUM ALP ISOZYME AND IT CHANGE DURING THE FASTING IN BEAGLE DOGS.
- P6-44 The effects of chronic dietary restriction on biological characteristics in Crj:CD(SD)IGS rats(DRUG METABOLISM/CARCINOGENICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Collaborative work on evaluation of ovarian toxicity : 11) Two- or four-week repeated-dose studies and fertility study of ethylene glycol monomethyl ether in female rats
- Gene expression profiling of rat kidneys following dose of edaravone in combination with cefalotin and glycerol(Kidney, Urinary system, Proceedings of the 32nd Annual Meeting)
- COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 25)EFFECTS OF 2- AND 4- WEEK REPEATED-DOSING OF DIBROMOACETIC ACID
- Gene expression profiling in rat primary-cultured hepatocytes exposed to chemicals causing mitochondrial dysfunction (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Preliminary investigation in application of microarray technique to toxicity evaluation using rat primary-cultured hepatocytes.(GENERAL SESSION BY POSTER PRESENTATION)(MOLECULAR TOXICITY & TOXICOGENOMICS)
- Mechanism for benzothiazole derivative-induced hepatotoxicity in rats(SYMPOSIUM 1 : MECHANISMS OF HEPATOTOXIC EFFECTS)
- TOXICOLOGICAL RESPONSE OF RATS TO A NOVEL MONOAMINE OXIDASE TYPE-A INHIBITOR, (5R)-3-[2-((1S)-3-CYANO-1-HYDROX-YPROPYL)BENZOTHIAZOL-6-YL]-5-METHOXYMETHYL-2-OXAZOLIDI-NONE (E2011), ORALLY ADMINISTERED FOR 13 WEEKS
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- Report 4 : CASE STUDY OF CARCINOGENICITY BY INITIATION-PROMOTION MODEL (CARCINOGENlClTY STUDIES)
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