KUPFFER CELL- MEDIATED CYTOTOXICITY INDUCED BY LIPOPOLYSACCHARIDE0111:B4 IS GREATER IN DOGS THAN IN RATS AND MONKEYS
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概要
- 論文の詳細を見る
To clarify the mechanism of sensitivity to an endotoxin lipopolysaccharide LPS0111:B4, which causes severe liver injury in a variety of animals, we have developed an in vitro assay to measure Kupffer cell-mediated cytotoxicity in the human liver cell line, WRL68. This assay could detect the decrease in Kupffer cell activity induced by gadolinium chloride (GdCl3), which is an inhibitor in Kupffer cells. Among Kupffer cells derived from dogs, rats, and monkeys, LPS-activated canine Kupffer cells exhibited remarkably high cytotoxicity against WRL68 cells. This species difference is correlated with a species difference in the lethality of LPS0111:B4. Additionally, the conditioned medium of LPS-activated canine Kupffer cells was also cytotoxic to WRL68 cells. To identify the mediators of this cytotoxicity, we measured the accelerated release of interleukin-1β, and interleukin-6 from Kupffer cells on stimulation with LPS0111:B4. From the correlation of the response to LPS0111:B4, interleukin-1β and interleukin-6 are considered to be responsible for the canine Kupffer cell-mediated cytotoxicity of LPS0111:B4.
- 日本トキシコロジー学会の論文
- 2002-02-25
著者
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MUTAI Mamoru
Toxicology Laboratory, Life Science Research Sector, Mitsubishi Chemical Co. Yokohama Research Cente
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Mutai M
Toxicology Laboratory Pharmaceuticals Research Unit Research & Development Division Mitsubishi P
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Mori Mie
Toxicology Laboratory Pharmaceuticals Research Unit Research & Development Division Mitsubishi P
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Mutai Mamoru
Toxicol.lab.life Sci.res.sect.mitsubishi Chemical Co. Ltd.
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Mutai M
Toxicology Laboratory Pharmaceuticals Research Division Mitsubishi Pharma Corporation
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Mutai Mamoru
Toxicology Laboratory Mitsubishi-tokyo Pharmaceuticals Inc.
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HAMANO TAKAKO
Toxicology Laboratory, Pharmaceuticals Research Division, Mitsubishi Pharma Corporation
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TONG VINCENT
Toxicology Laboratory, Pharmaceuticals Research Division, Mitsubishi Pharma Corporation
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HAYASHI MASAO
Department of Biology, Ochanomizu University
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TANAKA EIJI
Toxicology Laboratory, Pharmaceuticals Research Division, Mitsubishi Pharma Corporation
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HAYASHI Masao
Graduate School of Humanities and Sciences, Ochanomizu University
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Hayashi Masao
Department Of Biology Ochanomizu University
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Tong Vincent
Toxicology Laboratory Pharmaceuticals Research Division Mitsubishi Pharma Corporation
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Hamano Takako
Toxicology Laboratory Pharmaceuticals Research Unit Research & Development Division Mitsubishi P
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Hamano Takako
Toxicology Laboratory Pharmaceuticals Research Division Mitsubishi Pharma Corporation
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Tanaka Eiji
Toxicology Laboratory Pharmaceuticals Research Division Mitsubishi Pharma Corporation
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