Collaborative work on evaluation of ovarian toxicity : 17) Two- or four-week repeated-dose studies and fertility study of sulpiride in female rats
スポンサーリンク
概要
- 論文の詳細を見る
To find the appropriate dosing period to detect ovarian toxicity, sulpiride, a D2 antagonist was orally dosed to female rats at dose levels of 1, 10, and 100mg/kg/day daily for 2 or 4 weeks in repeated-dose toxicity studies. In addition, sulpiride at the same dose levels was given to female rats daily during the pre-mating period, mating period, and Days 0-7 of gestation to assess its effect on fertility. In ovarian histology in the 2-week study, increases in atretic follicle were seen at 1mg/kg or more and increases in follicular cysts at 10mg/kg or more. In the 4-week study, these findings were seen at 1mg/kg or more, and a decrease in large follicles was seen at 10mg/kg or more. Increased body weight gain was observed at 10mg/kg or more in the 2- and 4-week studies. The females in these groups exhibited development of mammary alveolus by sulpiride-induced hyperprolactinemia. In the fertility study, sulpiride-treated females showing persistent diestrus resulted in successful mating, and almost all females got pregnant. However, increased implantation loss was observed at 10mg/kg or more, which was considered to be caused by the adverse effect of sulpiride on oocyte development. From these results, sulpiride-induced ovarian toxicity was seen at 1mg/kg or more in the 2- and 4-week repeated-dose toxicity studies, and the observed ovarian changes were considered to be related to adverse effects on female fertility.
- 日本トキシコロジー学会の論文
著者
-
Mutai M
Safety Research Laboratory (kazusa) Mitsubishi Tanabe Pharma Corporation
-
Ube Masayuki
Safety Research Laboratory (Kazusa), Mitsubishi Tanabe Pharma Corporation
-
Inoue Yoshimi
Fac. Of Pharmaceutical Sciences Toho Univ.
-
Ube Masayuki
第一三共安全性研究所
-
Ube Masayuki
Safety Research Laboratory (kazusa) Mitsubishi Tanabe Pharma Corporation
-
Mutai M
Toxicology Laboratory Pharmaceuticals Research Unit Research & Development Division Mitsubishi P
-
Mutai Mamoru
First Department Of Pathology Nagoya City University Medical School
-
Mutai Mamoru
Toxicology Laboratory Yokohama Research Center Mitsubishi Chemical Corporation.
-
Sugimoto Jiro
Safety Research Laboratory (kazusa) Mitsubishi Tanabe Pharma Corporation
-
Sugimoto Jirou
Toxicology Laboratory Pharmaceuticals Research Unit Research & Development Division Mitsubishi P
-
ADACHI Tamiko
Safety Research Laboratory
-
Uno Yoshifumi
Safety Research Laboratory Mitsubishi Tanabe Parma Co.
-
Mutai M
Toxicology Laboratory Pharmaceuticals Research Division Mitsubishi Pharma Corporation
-
Ishii Shun-ichiro
Safety Research Laboratory (Kazusa), Mitsubishi Tanabe Pharma Corporation
-
Okada Miyoko
Safety Research Laboratory (Kazusa), Mitsubishi Tanabe Pharma Corporation
-
Inoue Yoshimi
Safety Research Laboratory (Kazusa), Mitsubishi Tanabe Pharma Corporation
-
Mutai Mamoru
Safety Research Laboratory (Kazusa), Mitsubishi Tanabe Pharma Corporation
-
Sugimoto Jiro
Toxicology Laboratory Pharmaceuticals Research Unit Research & Development Division Mitsubishi P
-
Uno Yoshifumi
Safety Research Laboratory (kazusa) Mitsubishi Tanabe Pharma Corporation
-
Inoue Yoshimi
Safety Research Laboratory (kazusa) Mitsubishi Tanabe Pharma Corporation
-
Okada Miyako
Safety Research Laboratory (kazusa) Mitsubishi Tanabe Pharma Corporation
-
Okada Miyoko
Mitsubishi-tokyo Pharmaceuticals Incorporation Yokohama Research Center Pharmacokinetics And Toxicol
-
Mutai Mamoru
Safety Research Laboratory (kazusa) Mitsubishi Tanabe Pharma Corporation
-
Adachi Tamiko
Safety Research Laboratory (kashima) Mitsubishi Tanabe Pharma Corporation
-
Adachi Tamiko
Safety Res. Lab. (kashima) Mitsubishi Tanabe Pharma Corp.
-
Ishii Shun-ichiro
Safety Research Laboratory (kazusa) Mitsubishi Tanabe Pharma Corporation
-
Ishii Shun-ichiro
Safety Evaluation Drug Development Laboratories Pharmaceutical Research Division Welfide Corporation
-
UNO Yoshifumi
Safety Research Laboratories, Mitsubishi Tanabe Pharma Co.
関連論文
- Dose-dependent Promoting Effects of Catechol on Glandular Stomach Carcinogenesis in BALB/c Mice Initiated with N-Methyl-N-nitrosourea
- Close Relation of Transforming Growth Factor-α Positive Hepatic Foci to Hepatocellular Tumor Development in the Rat
- Dose-related changes in gene expression in the livers of rats treated with sodium Phenobarbital as assessed using a three-dimensional microarray system. (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30t
- Transforming growth factor β derived from bone matrix promotes cell proliferation of prostate cancer and osteoclast activation-associated osteolysis in the bone microenvironment
- Prediction of carcinogenic potential by a toxicogenomic approach using rat hepatoma cells
- Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by leuprorelin, a luteinizing hormone-releasing hormone agonist
- Limited Effects of Disrupted Gap Junctions in the Liver on Multi-organ Carcinogenesis Induced by Diisopropanolnitrosamine in the Mutant Connexin 32 Transgenic Rat
- Downregulation of apoptosis revealed by laser microdissection and cDNA microarray analysis of related genes in rat liver preneoplastic lesions
- Inhibition of cell proliferation by nobiletin, a dietary phytochemical, associated with apoptosis and characteristic gene expression, but lack of effect on early rat hepatocarcinogenesis in vivo
- P8-29 The left lobe model as an improved mouse pulmonary fibrosis model by intratracheal bleomycin administration(STATISTICAL AND TEST METHODS/LOCAL STIMURATION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- B31 DETECTION OF HEPATOCARCINOGENIC POTENTIAL OF 5 CHEMICALS BY A MEDIUM-TERM BIOASSAY SYSTEM
- Collaborative work on evaluation of ovarian toxicity by repeated-dose and fertility studies in female rats
- OPTIMIZATION OF AN ANIMAL TEST PROTOCOL FOR TOXICOGENOMICS STUDIES (II); A CROSS-LABORATORY GENE EXPRESSION ANALYSIS
- OPTIMIZATION OF AN ANIMAL TEST PROTOCOL FOR TOXICOGENOMICS STUDIES (I); REQUIREMENT STUDY OF A PROTOCOL
- TWENTY-SIX WEEK CARCINOGENICITY STUDY OF AMPICILLIN IN CB6F1-TgrasH2 MICE
- IS II-3 In Vivo Comet Assay : Update on the On-Going Validation Coordinated by JaCVAM(Session II: In Vivo Tests)
- Transgenic Rats Carrying Human c-Ha-ras Proto-oncogene Are Highly Susceptible to N-Nitorosomethylbenzylamine Induction of Esphageal Tumorigenesis
- Harman and Norharman Suppressed but NaNO_2 Enhanced the Development of Preneoplastic Liver Cell Foci in 2-Amino-3,8-Dimethylimidazo[4,5-f]Quinoxaline (MeIQx)-Treated Rats
- Preferential mammary carcinogenic effects of 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine (PhIP) in human c-Ha-ras proto-oncogene transgenic rats
- Possible Chemopreventive Effects of Bovine Lactoferrin on Esophagus and Lung Carcinogenesis in the Rat
- Differential Dose-dependent Effects of α-, β-Carotenes and Lycopene on Gap-junctional Intercellular Communication in Rat Liver in vivo
- Inhibition of Azoxymethane-initiated Colon Tumor by Bovine Lactoferrin Administration in F344 Rats
- Triazine Derivatives Inhibit Rat Hepatocarcinogenesis but Do Not Enhance Gap Junctional Intercellular Communication
- Modifying Influence of Swine Serum-induced Liver Fibrosis on Development of Preneoplastic Lesions in Rat Liver
- Lack of effect of human c-Ha-ras proto-oncogene overexpression on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats
- 22A-10-3 Detection of Dibromoacetic acid-induced histopathological changes in testes and epididymides of rats by 2-weeks repeated dose toxicity study.
- 21C-10-2 Detection of carcinogenic potential of Diethylstibestrol (DES) and N-methyl-N-nitrosourea (MNU) by the alternative testing model using Tg-rasH2 mouse
- A Transgenic Rat Model of Prostate Carcinogenesis
- Collaborative work on evaluation of ovarian toxicity : 17) Two- or four-week repeated-dose studies and fertility study of sulpiride in female rats
- Effect of dosing interval between edaravone and cefalotin/glycerol on the nephrotoxicity in rats(Kidney, Urinary system, Proceedings of the 32nd Annual Meeting)
- P7-14 Renal Toxicity of Furosemide in Rats : Effects of Water-Deprived Condition or Coadministration of Cefalotin and Glycerol(IMMUNE AND ALLERGIC SYSTEM/KIDNEYS AND URINARY EXCRETION SYSTEM/CYTOTOXICITY/OTHERS-1)(GENERAL SESSION BY POSTER PRESENTATION)(P
- O-22 Nephrotoxic effect of edaravone in combination with cefalotin and glycerol in rats(KIDNEYS AND URINARY EXCRETION SYSTEM)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st Annual Meeting)
- 90-day repeated dose toxicity study of gum arabic(General toxicity, Proceedings of the 32nd Annual Meeting)
- LACK OF SIGNIFICANT ALTERATION IN THE PROSTATE OR TESTIS OF F344 RAT OFFSPRING AFTER TRANSPLACENTAL AND LACTATIONAL EXPOSURE TO BISPHENOL A
- Age-dependent histopathological findings in the prostate of probasin/SV40 T antigen transgenic rats : Lack of influence of carcinogen or testosterone treatment
- P11-09 Glucose Alters the Susceptibility of Mesangial Cells to Contrast Media.
- Species differences between rats and dogs in LPS-stimulated Kupffer cells and monocytes.(GENERAL SESSION BY POSTER PRESENTATION)(LIVER AND DIGESTIVE SYSTEM)
- KUPFFER CELL- MEDIATED CYTOTOXICITY INDUCED BY LIPOPOLYSACCHARIDE0111:B4 IS GREATER IN DOGS THAN IN RATS AND MONKEYS
- PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR α(PPARα)AGONIST, WY-14, 643, INCREASED TRANSCRIPTION OF MYOSIN LIGHT CHAIN-2 IN CARDIOMYOCYTES
- A Novel Mutation vf Causing Abnormal Vacuoles in the Central Nervous System Maps on Rat Chromosome 8
- Up-regulation of oxidative stress responsive genes in the rat kidney glomerulus following single intravenous dose of puromycin aminonucleoside (PAN) (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th An
- Metabonomic analysis of rat urine following single dose of α-naphthylisothiocyanate (ANIT) or puromycin aminonucleoside (PAN) (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- 3B-06 Study on the blood chemistry parameters in CD(SD)IGS rats.
- ORIGIN OF SERUM ALP ISOZYME AND IT CHANGE DURING THE FASTING IN BEAGLE DOGS.
- Gene expression profiling of rat kidneys following dose of edaravone in combination with cefalotin and glycerol(Kidney, Urinary system, Proceedings of the 32nd Annual Meeting)
- COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 25)EFFECTS OF 2- AND 4- WEEK REPEATED-DOSING OF DIBROMOACETIC ACID
- Gene expression profiling in rat primary-cultured hepatocytes exposed to chemicals causing mitochondrial dysfunction (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Preliminary investigation in application of microarray technique to toxicity evaluation using rat primary-cultured hepatocytes.(GENERAL SESSION BY POSTER PRESENTATION)(MOLECULAR TOXICITY & TOXICOGENOMICS)
- Induction of apoptosis in the LNCaP human prostate carcinoma cell line and prostate adenocarcinomas of SV40T antigen transgenic rats by the Bowman-Birk inhibitor
- Effects of Salt Loading on Glomeruli in the Remnant Kidney Model
- Report 4 : CASE STUDY OF CARCINOGENICITY BY INITIATION-PROMOTION MODEL (CARCINOGENlClTY STUDIES)
- P-89 Collaborative Work to Evaluate Repeated Dose Toxicity on Male Reproductive Organs in Rats. : Testicular Toxicity in Male Rats Given Adriamycin for Two or Four weesk(Proceedings of the 27th Annual Meeting)
- COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 9)TESTICULAR TOXICITY IN MALE RATS GIVEN ADRIAMYCIN FOR TWO OR FOUR WEEKS
- EFFECTS OF ADRIAMYCIN, AN ANTICANCER DRUG SHOWING TESTICULAR TOXICITY, ON FERTILITY IN MALE RATS (<SPECIAL ISSUE>TESTICULAR TOXICITY)
- P11-01 Development of in vitro assay for drug-induced myocardial hypertrophy
- Momordica charantia leaf extract suppresses rat prostate cancer progression in vitro and in vivo
- Tissue Sample Preparation for In Vivo Rodent Alkaline Comet Assay
- Lymphoid Hyperplasia of the Spleen of an 8-Week-Old Rat
- Promotion Effect of a Choline-deficient L-amino Acid-defined (CDAA) Diet on Hepatocellular Foci Formation Initiated by Diethylnitrosamine in Fischer 344 Rats