TWENTY-SIX WEEK CARCINOGENICITY STUDY OF AMPICILLIN IN CB6F1-TgrasH2 MICE
スポンサーリンク
概要
- 論文の詳細を見る
As a part of the ILSI-HESI Alternative to Carcinogenicity Testing (ACT) program, we performed a 26-week carcinogenetic study of nonmutagenic drug, ampicillin (ABPC) in Tg-rasH2 mice. ABPC was given to Tg-rasH2 mice (0, 350, 1000, 3000 mg/kg, p.o.) and Non-Tg mice (0, 3000 mg/kg, p.o.) daily for 26 weeks. As a positive control, a single dose of MNU was administered once to Tg-rasH2 mice (75 mg/kg, i.p.). In this study, Tg-rasH2 mice did not demonstrate any increases in tumor development in response to ABPC. Thus, ABPC had no carcinogenicity in the 26-week carcinogenesis study in Tg-rasH2 mice or in a 2-year carcinogenesis study in B6C3F1 mice.
- 日本トキシコロジー学会の論文
- 2002-08-22
著者
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KOBAYASHI Kinji
Safety Research Laboratory, Tanabe Seiyaku Co. Ltd.
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Honda Tatsuya
Safety Research Laboratory, Mitsubishi Tanabe Pharma Corporation
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Nishimura Tomonari
Safety Research Laboratory, Mitsubishi Tanabe Pharma Corporation
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YAMAGUCHI Chisato
Drug Safety Research Laboratories, Tanabe Seiyaku Co., Ltd.
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Kobayashi Kinji
Drug Safety Research Laboratories Tanabe Seiyaku Co. Ltd.
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Kobayashi Kinji
Safety Research Laboratory Tanabe Seiyaku Co. Ltd.
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FUJIWARA Toshihisa
Drug Safety Research Laboratories, TANABE Seiyaku Co., Ltd.
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ADACHI Tamiko
Drug Safety Research Laboratories, TANABE Seiyaku Co., Ltd.
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SASAKI Yoshifumi
Drug Safety Research Laboratories, TANABE Seiyaku Co., Ltd.
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ADACHI Tamiko
Safety Research Laboratory
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KUWAMURA Yuki
Safety Research Laboratory
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FUJIWARA Toshihisa
Safety Research Laboratory
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TANIMOTO Noriaki
Safety Research Laboratory
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KOGUCHI Atsushi
Safety Research Laboratory
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SASAKI Yoshifumi
Safety Research Laboratory
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YAMAGUCHI Chisato
Safety Research Laboratory
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KAWASHIMA Kazutaka
Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
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YUASA Hirofumi
Safety Research Laboratory
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YAMAMURA Takaaki
Safety Research Laboratory
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INUI Toshihide
Safety Research Laboratory
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Koguchi A
Safety Research Laboratory
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Honda Tatsuya
Safety Research Laboratory Mitsubishi Tanabe Pharma Corporation
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Kuwamura Y
Tanabe Seiyaku Co. Ltd. Safety Research Laboratory
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Adachi Tamiko
Drug Safety Research Laboratories Tanabe Seiyaku Co. Ltd.
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Yuasa Hirofumi
Tanabe Seiyaku Co. Ltd. Safety Research Laboratory
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Kobayashi K
Drug Safety Research Laboratories Tanabe Seiyaku Co. Ltd.
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Adachi Tamiko
Safety Res. Lab. (kashima) Mitsubishi Tanabe Pharma Corp.
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Sasaki Yoshifumi
Drug Safety Research Laboratories Tanabe Seiyaku Co. Ltd.
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Sasaki Yoshifumi
Safety Research Lab. Tanabe Seiyaku Co. Ltd.
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Yamaguchi Chisato
Drug Safety Research Laboratories Tanabe Seiyaku Co. Ltd.
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Nishimura T
Safety Research Laboratory Mitsubishi Tanabe Pharma Corporation
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Kawashima Kazutaka
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
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