EFFECTS OF ADRIAMYCIN, AN ANTICANCER DRUG SHOWING TESTICULAR TOXICITY, ON FERTILITY IN MALE RATS (<SPECIAL ISSUE>TESTICULAR TOXICITY)
スポンサーリンク
概要
- 論文の詳細を見る
Adriamycin (ADR), an anticancer drug, was intravenously administered to Slc : SD male rats at doses of 0, 1 and 2 mg/kg once a week for 4 or 9 weeks before pairing, and the treatment period and parameters suitable for detection of male fertility disorder were examined. No adverse effects were observed on the copulation index, fertility index and spermatozoa, but testicular weights were low in the 1 and 2 mg/kg groups after 4-week treatment. In the 2 mg/kg group after 9-week treatment, 11 of 12 males had died or became moribund, and no successful pregnancies were observed. The males in the 1 and 2 mg/kg groups after 9-week treatment had decreased weights of the genital organs, an extremely decreased number of sperm and low sperm motility as well as a low implantation rate and a decreased number of live fetuses. Microscopically, the numbers of spermatogonia were decreased in the 1 and 2 mg/kg groups after 4-week treatment, whereas the numbers of even spermatozoa were diminished and genital organs showed atrophy after 9-week treatment. These results indicate that 4-week treatment before pairing is sufficient to detect effects of ADR on the testis, especially on spermatogonia, and that microscopic findings and testis weight are appropriate parameters for detection of male fertility disorders.
- 日本トキシコロジー学会の論文
著者
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ADACHI Tamiko
Drug Safety Research Laboratories, TANABE Seiyaku Co., Ltd.
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ADACHI Tamiko
Safety Research Laboratory
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YAMAMURA Takaaki
Safety Research Laboratory
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IMAHIE Hiroshi
Safety Research Laboratory, Tanabe Seiyaku Co. Ltd.
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Nakagawa Yoko
Safety Research Laboratory Tanabe Seiyaku Co. Ltd.
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Adachi Tamiko
Drug Safety Research Laboratories Tanabe Seiyaku Co. Ltd.
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HORI Masaki
Safety Research Laboratory, Tanabe Seiyaku Co., Ltd.
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Hori Masaki
Safety Research Laboratory Tanabe Seiyaku Co. Ltd.
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Imahie H
Tanabe Seiyaku Co. Ltd. Osaka Jpn
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NAGASAKI Tohru
Safety Research Laboratory, Tanabe Seiyaku Co., Ltd.
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Adachi Tamiko
Safety Res. Lab. (kashima) Mitsubishi Tanabe Pharma Corp.
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Nagasaki Tohru
Safety Research Laboratory Tanabe Seiyaku Co. Ltd.
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Imahie Hiroshi
Safety Research Laboratory Research Division Mitsubishi Tanabe Pharma Corporation
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