HISTOPATHOLOGICAL STUDY ON EFFECTS OF POTASSIUM ASPARTATE ON THE HYPOTHALAMUS OF RATS
スポンサーリンク
概要
- 論文の詳細を見る
Rats of various ages were treated orally or intraperitoneally with potassium aspartate. The dose required to induce hypothalamic lesion varied considerably by the age of animals and route of administration. Additional experiment, in which the animals were orally treated three times a day with potassium aspartate in dose levels between the maximum safety dose and minimum lesion-producing dose in the preceding single dose study, revealed no hypothalamic lesion at all in any animals of each age group. In this condition, the maximum safety dose was 3-5 times as large as that in single dosage administration experiment. Regarding the safety evaluation of potassium aspartate preparations, brief discussions on some points in extrapolation of the results of the present experimental study to the clinical use were made.
- 日本トキシコロジー学会の論文
- 1979-02-15
著者
-
Okaniwa Azusa
Safety Research Lab. Tanabe Seiyaku Co. Ltd.
-
Wada Isao
Safety Research Laboratory Tanabe Seiyaku Co. Ltd.
-
HORI Masaki
Safety Research Laboratory, Tanabe Seiyaku Co., Ltd.
-
Hori Masaki
Safety Research Laboratory Tanabe Seiyaku Co. Ltd.
-
HAYASHI Nobumitsu
Safety Research Laboratory, Tanabe Seiyaku Co., Ltd.
-
MASUDA Mitsuhiro
Safety Research Laboratory, Tanabe Seiyaku Co., Ltd.
-
TAKESHITA Masakazu
Safety Research Laboratory, Tanabe Seiyaku Co., Ltd.
-
DOI Kunio
Pharmacological Research Laboratory, Tanabe Seiyaku Co., Ltd.
-
OHARA Yoshiki
Pharmacological Research Laboratory, Tanabe Seiyaku Co., Ltd.
-
Hayashi Nobumitsu
Safety Research Laboratory Tanabe Seiyaku Co. Ltd.
-
Takeshita Masakazu
Safety Research Laboratory Tanabe Seiyaku Co. Ltd.
-
Ohara Yoshiki
Pharmacological Research Laboratory Tanabe Seiyaku Co. Ltd.
-
Masuda Mitsuhiro
Safety Research Laboratory Tanabe Seiyaku Co. Ltd.
-
Doi Kunio
Pharmacological Research Laboratory Tanabe Seiyaku Co. Ltd.
-
OKANIWA Azusa
Safety Research Laboratory, Tanabe Seiyaku Co., Ltd.
関連論文
- A-8 CARDIOVASCULAR MALFORMATIONS INDUCED BY CAFFEINE IN CHICK EMBRYOS
- COMPARISON OF ARTERIAL BLOOD GASES AND ACID-BASE BALANCE IN YOUNG AND AGED BEAGLE DOGS, WITH REGARD TO POSTPRANDIAL ALKALINE TIDE
- A method for evaluation of angialgia in rats.
- EFFECTS OF ADRIAMYCIN, AN ANTICANCER DRUG SHOWING TESTICULAR TOXICITY, ON FERTILITY IN MALE RATS (<SPECIAL ISSUE>TESTICULAR TOXICITY)
- Effects of H-2 Histocompatibility Gene Complex on Urethan and Ethylnitrosourea(ENU)-Induced Malformations in Mice
- OCULAR TOXICITY STUDY WITH BEAGLE DOGS (ON ZINC PYRIDINETHI-ONE POISONING, A MODEL OF THE OPHTHALMOLOGIC DISORDER) 2. HISTOPATHOLOGICAL FINDINGS
- OCULAR TOXICITY STUDY WITH BEAGLE DOGS (ON ZINC PYRIDINETHI-ONE POISONING, A MODEL OF THE OPHTHALMOLOGIC DISORDER) 1. CLINICAL FINDINGS
- HISTOPATHOLOGICAL STUDY ON EFFECTS OF POTASSIUM ASPARTATE ON THE HYPOTHALAMUS OF RATS
- Immunotoxicological studies of anti-cancer drugs.