COMPARISON OF ARTERIAL BLOOD GASES AND ACID-BASE BALANCE IN YOUNG AND AGED BEAGLE DOGS, WITH REGARD TO POSTPRANDIAL ALKALINE TIDE

スポンサーリンク

概要

• 論文の詳細を見る

• Arterial blood pH and blood gas tensions were measured before and after feeding in seven young(1-year-old)and 6 aged(10 to 12 year-old)conscious beagle dogs with a portable "i-STAT"blood gas analyzer to obtain the fundamental physiological data on the laboratory dogs. Before feeding, arterial blood pH, HCO_3^- and base excess(BE)were 7.395±0.022, 20±1.0 mmol/L and -4±1.1 mmol/L in young dogs, and 7.408±0.031, 23±1.5 mmol/L and -2±1.8 mmol/L in aged ones. After feeding, the above values changed to 7.449±0.021, 25±1.1 and 1±1.3 in young dogs, and 7.456±0.022, 28±1.7 and 4±1.9 in aged ones. After feeding, each of the values for pH, HCO_3^- and BE was increased in comparison with those before feeding in both young and aged dogs, and alkalinization of blood, the alkaline tide, was observed in all healthy dogs. The values for PCO_2 also rose from 33.6±1.91 to 36.7±1.95(mmHg)in young dogs, and 36.4±2.97 to 40.3±3.06(mmHg)in aged ones, and in 3 of 6 aged dogs slight hypoxia(PO_2<80 mmHg)was noted. These changes in PCO_2 and PO_2 were considered to be due to compensatory hypoventilation for the alkalinization of blood. To confirm the cause of the alkaline tide phenomenon, we investigated the association of the alkaline tide with gastiric acid secretion by cimetidine, an H_2-blocker ; and found that it was effective to inhibit postprandial alkaline tide in dogs. After feeding, ionized Ca concentration(iCa)was decreased inversely with an arterial blood pH increase in both young and aged dogs. The mean values of iCa in aged dogs after feeding was lower than those in young dogs. In the present experiments, it was demonstrated that in beagle dogs the acid-base balance and blood gas values were largely affected by feeding, especially in aged dogs. In case blood gases would be evaluated in toxicity studies, we should consider the influence of feeding and aging.

• 日本トキシコロジー学会の論文
• 2000-08-17

著者

• TANIMOTO Noriaki

  Safety Research Laboratory

• Ozaki Junichiro

  Safety Research Laboratory Tanabe Seiyaku Co. Ltd.

• KUSE Hiroshi

  Safety Research Laboratory, Tanabe Seiyaku Co., Ltd.

• HORI Masaki

  Safety Research Laboratory, Tanabe Seiyaku Co., Ltd.

• Kuse Hiroshi

  Safety Research Laboratory Tanabe Seiyaku Co. Ltd.

• Hori Masaki

  Safety Research Laboratory Tanabe Seiyaku Co. Ltd.

• Tanimoto N

  Tanabe Seiyaku Co. Ltd. Osaka Jpn

関連論文

• TWENTY-SIX WEEK CARCINOGENICITY STUDY OF AMPICILLIN IN CB6F1-TgrasH2 MICE
• COMPARISON OF ARTERIAL BLOOD GASES AND ACID-BASE BALANCE IN YOUNG AND AGED BEAGLE DOGS, WITH REGARD TO POSTPRANDIAL ALKALINE TIDE
• A method for evaluation of angialgia in rats.
• EFFECTS OF ADRIAMYCIN, AN ANTICANCER DRUG SHOWING TESTICULAR TOXICITY, ON FERTILITY IN MALE RATS (<SPECIAL ISSUE>TESTICULAR TOXICITY)
• OCULAR TOXICITY STUDY WITH BEAGLE DOGS (ON ZINC PYRIDINETHI-ONE POISONING, A MODEL OF THE OPHTHALMOLOGIC DISORDER) 2. HISTOPATHOLOGICAL FINDINGS
• OCULAR TOXICITY STUDY WITH BEAGLE DOGS (ON ZINC PYRIDINETHI-ONE POISONING, A MODEL OF THE OPHTHALMOLOGIC DISORDER) 1. CLINICAL FINDINGS
• HISTOPATHOLOGICAL STUDY ON EFFECTS OF POTASSIUM ASPARTATE ON THE HYPOTHALAMUS OF RATS
• Auditory Brainstem Response (ABR) in Beagles as an Auditory Functional Test
• Immunotoxicological studies of anti-cancer drugs.

スポンサーリンク