A Hepatocellular Adenoma in a Diet-induced Obese Mouse
スポンサーリンク
概要
- 論文の詳細を見る
A hepatic nodule was noted in a C57BL/6J mouse with diet-induced obesity at 53 weeks of age. Macroscopically, a protruding yellowish white nodule was observed on the visceral surface of the left lateral lobe. Light microscopy demonstrated clear demarcation from the compressed adjacent parenchyma, with loss of the distinct lobular pattern. The proliferating cells of the lesion varied in shape and showed cellular atypia and prominent nucleoli along with vacuoles of various sizes. Some of the cells contained various-sized eosinophilic inclusion bodies in their cytoplasm, and electron microscopy revealed the presence of lipid droplets in the rough endoplasmic reticulum. Eosinophilic inclusions were observed as electron dense granular material in the rough endoplasmic reticulum, with one or a few low density central cores. A diagnosis of hepatocellular adenoma was made based on these findings.
著者
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FUJIWARA Toshihisa
Safety Research Laboratory
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Ide Mika
Safety Research Laboratory, Mitsubishi Tanabe Pharma Corporation
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Kawai Kouji
Safety Research Laboratory, Mitsubishi Tanabe Pharma Corporation
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Sakairi Tetsuya
Safety Research Laboratory, Mitsubishi Tanabe Pharma Corporation
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Tanaka Masaharu
Advanced Medical Research Laboratory, Mitsubishi Tanabe Pharma Corporation
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Shinozuka Junko
Safety Research Laboratory, Mitsubishi Tanabe Pharma Corporation
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Sato Hiroko
Safety Research Laboratory, Mitsubishi Tanabe Pharma Corporation
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Sano Fumiko
Safety Research Laboratory, Mitsubishi Tanabe Pharma Corporation
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Kume Eisuke
Safety Research Laboratory, Mitsubishi Tanabe Pharma Corporation
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