Acute Thrombus Formation in the Lungs of Phenylhydrazine-treated Rats
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概要
- 論文の詳細を見る
We report pathological changes observed in the lungs of Phenylhydrazine (PHZ)-treated rats. Seven male SD rats were treated intraperitoneally with 50 mg/kg/day of PHZ for 3 days. PHZ-treated rats developed severe hemolytic anemia, and four out of the seven rats died after the final administration of PHZ; the three surviving rats were terminally sacrificed 24 hours after the final administration. Macroscopically, all lobes of the lungs of PHZ-treated rats were red or dark, and small white lesions were observed in the terminally sacrificed rats after fixation. Light microscopy revealed deposition of eosinophilic material in the alveolar septa of all PHZ-treated rats. This eosinophilic material was identified as fibrin (fibrin thrombus formation) in alveolar capillaries by immunohistochemistry and electron microscopy. This is the first report showing that PHZ induces acute thrombus formation in animals.
- 日本毒性病理学会の論文
- 2008-12-30
著者
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Shinozuka Junko
Safety Research Laboratory, Mitsubishi Tanabe Pharma Corporation
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Sato Hiroko
Safety Research Laboratory, Mitsubishi Tanabe Pharma Corporation
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Tanaka Masaharu
Safety Research Laboratories Fukui Institute Ono Pharmaceutical Co. Ltd.
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Toriumi Wataru
Safety Research Laboratory Mitsubishi Tanabe Pharma Co.
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FUJIMURA Hisako
Safety Research Laboratory, Mitsubishi Tanabe Pharma Co.
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Shinozuka Junko
Safety Research Laboratory Mitsubishi Tanabe Pharma Co.
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Sato Hiroko
Safety Research Laboratory Mitsubishi Tanabe Pharma Co.
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Fujimura Hisako
Safety Research Laboratory Mitsubishi Tanabe Pharma Co.
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