Metabolic Fingerprinting in Toxicological Assessment Using FT-ICR MS
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概要
- 論文の詳細を見る
Detection of the toxicity of a candidate compound at an early stage of drug development is an emerging area of interest. It is difficult to determine all of the effects of metabolism of a compound using traditional approaches such as histopathology and serum biochemistry. The goal of a metabolomics approach is to determine all metabolites in a living system, with the potential to detect and identify biomarkers involved in toxicity onset. Here, we summarize the metabolic fingerprints for detection and identification of metabolic changes and biomarkers related to drug-induced toxicity using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS).
- 日本毒性病理学会の論文
著者
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YAMATE JYOJI
Department of Veterinary Pathology, Graduate School of Agricultural Lifesciences
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Takenaka Shigeo
Department of Veterinary Science, Osaka Prefecture University
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KUWAMURA Mitsuru
Department of Veterinary Pathology, Graduate School of Agriculture and Biological Sciences, Osaka Pr
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Yamate Jyoji
Department Of Veterinary Pathology Graduate School Of Agriculture And Biological Science Osaka Prefe
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Takenaka Shigeo
Department Of Mathematics Hiroshima University
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Hasegawa Mina
Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefectu
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Ide Mika
Safety Research Laboratory, Mitsubishi Tanabe Pharma Corporation
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Hasegawa Mina
Department Of Veterinary Science Graduate School Of Life And Environmental Sciences Osaka Prefecture
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Hasegawa Mina
Department Of Veterinary Sciences Osaka Prefecture University
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