Comparative Nephrotoxicity of Cisplatin and Nedaplatin:Mechanisms and Histopathological Characteristics
スポンサーリンク
概要
- 論文の詳細を見る
The antineoplastic platinum complexes cisplatin and its analogues are widely used in the chemotherapy of a variety of human malignancies, and are especially active against several types of cancers. Nedaplatin is a second-generation platinum complex with reduced nephrotoxicity. However, their use commonly causes nephrotoxicity due to a lack of tumor tissue selectivity. Several recent studies have provided significant insights into the molecular and histopathological events associated with nedaplatin nephrotoxicity. In this review, we summarize findings concerning the renal histopathology and molecular pathogenesis induced by antineoplastic platinum complexes, with a particular focus on the comparative nephrotoxicity of cisplatin and nedaplatin in rats.
著者
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Yamate Jyoji
Department Of Veterinary Pathology Graduate School Of Agriculture And Biological Science Osaka Prefe
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Uehara Takeki
Developmental Research Laboratories Shionogi & Co. Ltd.
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Torii Mikinori
Drug Safety Evaluation Developmental Res. Laboratories Shionogi & Co. Ltd. Jpn
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Uehara Takeki
Drug Safety Evaluation, Drug Developmental Research Laboratories, Shionogi & Co., Ltd.
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Maruyama Toshiyuki
Drug Safety Evaluation, Drug Developmental Research Laboratories, Shionogi & Co., Ltd.
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Torii Mikinori
Drug Developmental Research Laboratories Shionogi & Co. Ltd.
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