Age-dependent Decrease in Incidence of Rat Sperm Granulomas Induced by L-Cysteine
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概要
- 論文の詳細を見る
The pathogenesis of sperm granulomas is very complicated, and leakage of spermatozoa into extraluminal tissues is regarded as a crucial event. We previously reported that sperm granulomas were frequently induced in the epididymides of pubertal rats by excessive dose of L-cysteine (L-Cys). Here, we compared the incidence of sperm granulomas between L-Cys-treated pubertal (6-week-old) and adult (11-week-old) rats by intraperitoneally injecting daily with L-Cys (800 mg/kg body weight) for 4 weeks. L-Cys-induced sperm granulomas were seen in 6 rats of 10 L-Cys-treated pubertal rats, whereas only one rat in 40 L-Cys-treated adult rats developed a sperm granuloma, indicating age-dependent decrease in the frequency. In L-Cys-treated pubertal rats, additionally, small ducts (indicative of immaturity), dilated ducts, and interstitial edema were frequently seen, but such findings were rarely present in L-Cys-treated adult rats. The accumulation of spermatozoa in epididymal ducts was often observed both in L-Cys-treated pubertal and adult rats. These findings indicated that the administration with a large amount of L-Cys might have disturbed the luminal microenvironments, with greater influence on pubertal rats than adult rats. Particularly, the findings, that the incidences of small ducts and sperm granulomas were high in L-Cys-treated pubertal rats and low in L-Cys-treated adult rats, suggested that the prerequisite for sperm granuloma formation might be associated mainly with the delayed maturation of epididymal ducts seen exclusively in pubertal rats due to excessive dose of L-Cys.
- 日本毒性病理学会の論文
- 2003-06-30
著者
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Kotani Takao
大阪府立大学 獣医病理学
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Kotani Takao
Vet. Pathol. Osaka Pref. Uni.
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YAMATE JYOJI
Department of Veterinary Pathology, Graduate School of Agricultural Lifesciences
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SAWAMOTO Osamu
Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc.
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KUWAMURA Mitsuru
Department of Veterinary Pathology, Graduate School of Agriculture and Biological Sciences, Osaka Pr
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KOTANI Takao
Department of Veterinary Pathology, Graduate School of Agriculture and Biological Sciences, Osaka Pr
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Kuwamura Mitsuru
Dept. Vet. Pathol. U. Of Osaka Pref.
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Yamate J
大阪府立大学大学院生命環境科学研究科
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Yamate Jyoji
Department Of Veterinary Pathology Graduate School Of Agriculture And Biological Science Osaka Prefe
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Sawamoto Osamu
Division Of Pharmacology Drug Safety And Metabolism Otsuka Pharmaceutical Factory Inc.
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Kuwamura Mitsuru
Vet. Pathol. Osaka Pref. Uni.
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YAMATE Jyoji
Department of Integrated Structural Biosciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
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KOTANI Takao
Vet. Pathol., Osaka Pref. Uni.
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KUWAMURA Mitsuru
Department of Integrated Structural Biosciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
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Kotani Takao
Department of Applied Mathematics and Physics, Tottori University, Tottori 680-8552, Japan
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