Preferential Induction of Mammary Tumors in p53 Hemizygous BALB/c Mice by Fractionated Irradiation of a Sub-lethal Dose of X-rays
スポンサーリンク
概要
- 論文の詳細を見る
BALB/c mice are susceptible to radiation-induced mammary tumors as well as lymphomas. We investigated the effects of the p53 deficient allele and of X-irradiation on the tumor spectrum in the BALB/c background. Substantially all p53 -/- animals died of thymic lymphomas before 36 weeks of age, while none of the p53 +/+ animals died during that period. At this age, mortalities of p53 +/- females and males were 5% (1/22) and 11% (1/9), respectively, due to non-thymic lymphoma and sarcoma. When exposed to 4 Gy of Xirradiation, 100% (44/44) and 95% (18/19) of p53 +/- mice died with tumors within 36 weeks. Among these, the predominant cause of death was lymphoma in either sex [26/44 (59%) in females; 13/19 (68%) in males]; mammary adenocarcinoma (15/44, 34%) and sarcoma (3/19, 16%) were semi-dominant in females and males, respectively. The mortalities of similarly treated p53 +/+ mice were 16% (5/31) in females and 17% (3/18) in males: virtually all deaths were due to thymic lymphomas in either sex. When exposed to 4 × 0.7 Gy of X-irradiation at weekly intervals, 23/23 (100%) of the p53 +/- females died of tumors within 36 weeks. In these animals, mammary adenocarcinoma (15/23, 65%), instead of lymphoma (7/23, 30%), was dominant. None of the similarly treated p53 +/+ females developed malignant tumors during the period. Mammary adenocarcinomas generated in p53 +/- females exposed or non-exposed to radiation showed a frequent loss of the p53 wild-type allele. Hence, we provided a useful experimental system to study radiation-induced mammary tumors in mice.
- 日本放射線影響学会の論文
著者
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Hong Doo-pyo
大阪府立大学 生命環境科学研究科
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Hong Doo-pyo
Graduate School Of Agriculture And Biological Sciences Osaka Prefecture University
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MORI NOBUKO
Research Institute for Advanced Science &Technology, Osaka Prefecture University
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YAMATE JYOJI
Department of Veterinary Pathology, Graduate School of Agricultural Lifesciences
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UMESAKO SEI-ICHI
Research Institute for Advanced Science &Technology, Osaka Prefecture University
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HONG DOO-PYO
Research Institute for Advanced Science &Technology, Osaka Prefecture University
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OKUMOTO MASAAKI
Research Institute for Advanced Science &Technology, Osaka Prefecture University
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NAKAO REN
Research Institute for Advanced Science &Technology, Osaka Prefecture University
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Okamoto Mieko
Experimental Radiobiology For Children's Health Research Group Research Center For Radiation Pr
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Okumoto M
Graduate School Of Agriculture And Biological Sciences Osaka Prefecture University:research Institut
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Okumoto Masaaki
大阪府立大学 生命環境科学研究科
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Okumoto Masaaki
Res. Inst. Advan. Sci. Technol. Osaka Prefecture Univ.
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Okumoto Masaaki
Graduate School Of Agriculture And Biological Sciences Osaka Prefecture University
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Nakao Ren
Research Institute For Advanced Science &technology Osaka Prefecture University
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Umesako Seiichi
Graduate School Of Agriculture And Biological Sciences Osaka Prefecture University
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Umesako Sei-ichi
Res. Inst. Advan. Sci. Technol. Osaka Prefecture Univ.
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Mori N
Graduate School Of Agriculture And Biological Sciences Osaka Prefecture University:research Institut
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Mori Nobuko
大阪府立大学 生命環境科学研究科
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Mori Nobuko
Department Of Applied Bioscience Research Institute Of Advanced Science & Technology University
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Yamate J
大阪府立大学大学院生命環境科学研究科
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Yamate Jyoji
Department Of Veterinary Pathology Graduate School Of Agriculture And Biological Science Osaka Prefe
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Mori Nobuko
Res. Inst. For Advan. Sci. &technol. Osaka Pre-fecture University.
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YAMATE Jyoji
Department of Integrated Structural Biosciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
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