Putative Tumor-suppressor Gene Regions Responsible for Radiation Lymphomagenesis in F_1 Mice with Different p53 Status

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概要

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• Regions of allelic loss on chromosomes in many tumors of human and some experimental animals are generally considered to harbor tumor-suppressor genes involved in tumorigenesis. Allelotype analyses have greatly improved our understanding of the molecular mechanism of radiation lymphomagenesis. Previously, we and others found frequent loss of heterozygosity (LOH) on chromosomes 4, 11, 12, 16 and 19 in radiation-induced lymphomas from several F_1 hybrid mice. To examine possible contributions of individual tumor-suppressor genes to tumorigenesis in p53 heterozygous deficiency, we investigated the genome-wide distribution and status of LOH in radiation-induced lymphomas from F_1 mice with different p53 status. In this study, we found frequent LOH (more than 20%) on chromosomes 4 and 12 and on chromosomes 11, 12, 16 and 19 in radiation-induced lymphomas from (STS/A X MSM/Ms)F_1 mice and (STS/A X MSM/Ms)F1-p53^<KO/+> mice, respectively. Low incidences of LOH (10-20%) were also observed on chromosomes 11 in mice with wild-type p53, and chromosomes 1, 2, 9, 17 and X in p53 heterozygous-deficient mice. The frequency of LOH on chromosomes 9 and 11 increased in the (STS/A X MSM/Ms)F_1-p53^<KO/+> mice. Preferential losses of the STS-derived allele on chromosome 9 and wild-type p53 allele on chromosome 11 were also found in the p53 heterozygous-deficient mice. Thus, the putative tumor-suppressor gene regions responsible for lymphomaganesis might considerably differ due to the p53 status.

• 日本放射線影響学会の論文

著者

• Park Yeong-gwan

  大阪府立大学先端科学研究所

• Park Yeong-gwan

  Research Institute For Advanced Science And Technology Osaka Prefecture University:graduate School O

• Aizawa Shiro

  放射線医学総合研究所

• Aizawa Shiro

  Division Of Biology And Oncology National Institute Of Radiological Sciences

• Song C‐w

  Korea Institute Of Toxicology Korea Research Institute Of Chemical Technology

• Song Chang-woo

  大阪府立大学 生命環境科学研究科

• Hong Doo-pyo

  大阪府立大学 生命環境科学研究科

• Hong Doo-pyo

  Graduate School Of Agriculture And Biological Sciences Osaka Prefecture University

• SONG Chang-Woo

  Korea Institute of Toxicology, Korea Research Institute of Chemical Technology

• MORI NOBUKO

  Research Institute for Advanced Science &Technology, Osaka Prefecture University

• HONG DOO-PYO

  Research Institute for Advanced Science &Technology, Osaka Prefecture University

• OKUMOTO MASAAKI

  Research Institute for Advanced Science &Technology, Osaka Prefecture University

• UMESAKO SEIICHI

  Research Institute for Advanced Science and Technology, OsakaPrefecture University

• Okamoto Mieko

  Experimental Radiobiology For Children's Health Research Group Research Center For Radiation Pr

• Okumoto M

  Graduate School Of Agriculture And Biological Sciences Osaka Prefecture University:research Institut

• Okumoto Masaaki

  大阪府立大学 生命環境科学研究科

• Okumoto Masaaki

  Res. Inst. Advan. Sci. Technol. Osaka Prefecture Univ.

• Okumoto Masaaki

  Graduate School Of Agriculture And Biological Sciences Osaka Prefecture University

• Umesako Seiichi

  Graduate School Of Agriculture And Biological Sciences Osaka Prefecture University

• Umesako Sei-ichi

  Res. Inst. Advan. Sci. Technol. Osaka Prefecture Univ.

• Song Chang-woo

  Korea Institute Of Toxicology

• Mori N

  Graduate School Of Agriculture And Biological Sciences Osaka Prefecture University:research Institut

• Mori Nobuko

  大阪府立大学 生命環境科学研究科

• Mori Nobuko

  Department Of Applied Bioscience Research Institute Of Advanced Science & Technology University

• Mori Nobuko

  Res. Inst. For Advan. Sci. &technol. Osaka Pre-fecture University.

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