Generation of Large Homozygous Chromosomal Segments by Mitotic Recombination during Lymphomagenesis in F1 Hybrid Mice

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概要

• 論文の詳細を見る

• The loss of heterozygosity (LOH) has been reported in numerous neoplasms in both human and animals, and has often been observed in chromosomal regions, which contain tumor-suppressor genes. We previously found frequent LOH on chromosomes 4, 12 and 19 in radiationinduced lymphomas from (BALB/cHeA x STS/A)F1 hybrid mice by allelotype analysis at polymorphic microsatellite loci. In this study, to elucidate the nature of allelic losses, we refined the loss regions on chromosomes 4, 12 and 19 of the tumors from the F1 mice and then analyzed them cytogenetically. The results represent evidence of a wide range of allelic losses owing to mitotic recombination on chromosomes 4 and 19 in the tumors, possibly reflecting functional losses of putative tumor-suppressor genes. It is suggested that the generation of these large homozygous chromosomal segments probably containing the affected genes is one of the genetic alterations responsible for tumorigenesis.

• 日本放射線影響学会の論文

著者

• Song C‐w

  Korea Institute Of Toxicology Korea Research Institute Of Chemical Technology

• Song Chang-woo

  大阪府立大学 生命環境科学研究科

• Hong Doo-pyo

  大阪府立大学 生命環境科学研究科

• Hong Doo-pyo

  Graduate School Of Agriculture And Biological Sciences Osaka Prefecture University

• SONG Chang-Woo

  Korea Institute of Toxicology, Korea Research Institute of Chemical Technology

• MORI NOBUKO

  Research Institute for Advanced Science &Technology, Osaka Prefecture University

• HONG DOO-PYO

  Research Institute for Advanced Science &Technology, Osaka Prefecture University

• OKUMOTO MASAAKI

  Research Institute for Advanced Science &Technology, Osaka Prefecture University

• KUBO KIHEI

  Graduate school of Agriculture and Biological Sciences, Osaka Prefecture University

• TSUGAWA NAOMI

  Graduate school of Agriculture and Biological Sciences, Osaka Prefecture University

• UMESAKO SEIICHI

  Research Institute for Advanced Science and Technology, OsakaPrefecture University

• Okamoto Mieko

  Experimental Radiobiology For Children's Health Research Group Research Center For Radiation Pr

• Okumoto M

  Graduate School Of Agriculture And Biological Sciences Osaka Prefecture University:research Institut

• Okumoto Masaaki

  大阪府立大学 生命環境科学研究科

• Okumoto Masaaki

  Res. Inst. Advan. Sci. Technol. Osaka Prefecture Univ.

• Okumoto Masaaki

  Graduate School Of Agriculture And Biological Sciences Osaka Prefecture University

• Umesako Seiichi

  Graduate School Of Agriculture And Biological Sciences Osaka Prefecture University

• Umesako Sei-ichi

  Res. Inst. Advan. Sci. Technol. Osaka Prefecture Univ.

• Song Chang-woo

  Korea Institute Of Toxicology

• Tsugawa Naomi

  Graduate School Of Agriculture And Biological Sciences Osaka Prefecture University

• Kubo K

  Lab. Vet. Rradiol. Div. Sci. Graduate Sch. Agr. & Biol. Sci. Osaka Pref. Univ.

• Kubo Kihei

  Department Of Advanced Pathobiology Graduate School Of Life & Environmental Sciences Osaka Prefe

• Kubo Kihei

  大阪府立大学 生命環境科学部先端病態解析学

• Kubo Kihei

  Department Of Veterinary Science Graduate School Of Agriculture And Biological Science Osaka Prefect

• Kubo Kihei

  Laboratory Of Veterinary Radiology Department Of Veterinary Medicine College Of Agriculture Osaka Pr

• Mori N

  Graduate School Of Agriculture And Biological Sciences Osaka Prefecture University:research Institut

• Mori Nobuko

  大阪府立大学 生命環境科学研究科

• Mori Nobuko

  Department Of Applied Bioscience Research Institute Of Advanced Science & Technology University

• Kubo Kihei

  Dept. Vet. Sci. Osaka Prefecture University

• Mori Nobuko

  Res. Inst. For Advan. Sci. &technol. Osaka Pre-fecture University.

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