Establishment of cell lines from human osteosarcoma.
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概要
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Four kinds of cell lines (OST1, OST1-M, OST2, OST3) were established from human osteosarcoma through the transplantation into nude mice of biopsied tumors. OST1 and OST1-M cells were respectively derived from primary and metastatic lesions of a patient. The original cells for OST1 were sampled before the therapy, while those for OST1-M were extracted after the chemotherapy and radiotherapy. Q-banding analysis showed that the chromosomal composition was different between the two cell lines. Also, the marker chromosomes in OST1-M cells contained a number of abnormally stretched one which probably resulted from gene amplification.
著者
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Kubo Kihei
Department Of Advanced Pathobiology Graduate School Of Life & Environmental Sciences Osaka Prefe
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Morita Kazuo
Department of Computer Science, The University of Electro-Communications
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KOIWAI Soichiro
Department of Radiology, Sapporo Medical College
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SHIDOU Mitsuo
Department of Radiology, Sapporo Medical College
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