p53 Dependency of Radio-adaptive Responses in Endogenous Spleen Colonies and Peripheral Blood-cell Counts in C57BL Mice
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概要
- 論文の詳細を見る
Radio-adaptive responses at a conditioning X-ray dose of 0.45 Gy and a challenging dose of 5.0 Gy on hematopoietic indices were studied in C57BL mice with p53(Trp53) wild, heterogenous and knockout allele. The conditioning irradiation, given 2 weeks before the challenging irradiation, induced radio-adaptive responses observed as a recovery of the peripheral blood-cell counts of leukocytes, thrombocytes and erythrocytes on day 14 after challenging irradiation in C57BL mice of the wild-type p53(+/+). The pre-irradiation also increased the endogenous spleen colonies (endo-CFU-S) on day 12 and the spleen weight on day 14. On the contrary, the knockout p53(-/-) mice gave no such radio-adaptive response. The heterogenous p53(+/-) mice gave an intermediate response. The radio-adaptive response in hematopoiesis at a challenge dose of 5.0 Gy seems to be a p53-dependent phenomenon. The possible role of induction in radioresistance through the reduction of p53-drived apoptosis in hematopoietic stem cells in pre-irradiated mice is discussed.
- 日本放射線影響学会の論文
著者
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Kubo K
Lab. Vet. Rradiol. Div. Sci. Graduate Sch. Agr. & Biol. Sci. Osaka Pref. Univ.
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Kubo Kihei
Department Of Advanced Pathobiology Graduate School Of Life & Environmental Sciences Osaka Prefe
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Kubo Kihei
大阪府立大学 生命環境科学部先端病態解析学
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Kubo Kihei
Department Of Veterinary Science Graduate School Of Agriculture And Biological Science Osaka Prefect
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Kubo Kihei
Laboratory Of Veterinary Radiology Department Of Veterinary Medicine College Of Agriculture Osaka Pr
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Horie Kiyohito
Lab. Vet. Rradiol. Div. Sci. Graduate Sch. Agr. & Biol. Sci. Osaka Pref. Univ.
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Yonezawa M
Div. Radiat. Biol. & Health Sci. Res. Inst. Adv. Sci. & Technol. Osaka Pref. Univ.
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Kubo Kihei
Dept. Vet. Sci. Osaka Prefecture University
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HORIE KIYOHITO
Laboratory of Veterinary Radiology, Division of Veterinary Science, Graduate School of Agriculture a
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YONEZAWA MORIO
Division of Radiation Biology and Health Science, Research Institute for Advanced Science and Techno
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