Novel Putative Fragile Sites Observed in Feline Fibroblasts Treated with Aphidicolin and Fluorodeoxyuridine.
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概要
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Fragile sites are non-randomly distributed chromosomal breaks and gaps observed in the cells cultivated under certain conditions. Feline fragile sites were analyzed using skin fibroblast strains after the treatments with aphidicolin and fluorodeoxyuridine in combination with caffeine. Three aphidicolin-induced fragile sites (A1q21, C2q13 and E1p21) as well as a folate-sensitive site (B1q14) were observed in all the 3 fibroblast strains tested for each treatment group. The loci in A1q21 and B1q14 are very close to that reported previously for peripheral blood lymphocytes and lung cells. Two chromosomal break points in C2q13 and E1p21 seem to be new fragile sites. Fifteen candidates for feline fragile sites were also assigned their locations in feline chromosomes. Both the incidence and distribution of feline fragile sites in skin fibroblasts seem to be different at least in part from those in lymphocytes.
- 公益社団法人 日本獣医学会の論文
著者
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Kubo Kihei
Laboratory Of Veterinary Radiology Department Of Veterinary Medicine College Of Agriculture Osaka Pr
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Matsuyama Satoshi
Laboratory Of Advanced Science And Technology For Industry University Of Hyogo
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Takamori Yasuhiko
Laboratory Of Veterinary Radiology Department Of Veterinary Medicine College Of Agriculture Osaka Pr
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Ito Yuko
Laboratory Of Anatomy Department Of Biomedical Sciences School Of Veterinary Medicine Hokkaido Unive
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Ohashi Fumihito
Laboratory Of Veterinary Surgery Osaka Prefecture University
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TAKAMORI Yasuhiko
Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Agriculture, Osaka Prefecture University
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SATO Kouji
Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Agriculture, Osaka Prefecture University
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SHIOMI Akiko
Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Agriculture, Osaka Prefecture University
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ONO Keiiti
Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Agriculture, Osaka Prefecture University
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KUBO Kihei
Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Agriculture, Osaka Prefecture University
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MATSUYAMA Satoshi
Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Agriculture, Osaka Prefecture University
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