Relationship between Major Histocompatibility Complex Class I Expression and Prognosis in Canine Mammary Gland Tumors
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概要
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The aim of this study was to evaluate MHC class I expression and prognosis using tumor tissues surgically removed from 9 dogs with mammary gland carcinomas and from 13 with complex mammary carcinomas. We assessed MHC class I expression and its correlation with tumor size, B2M expression, infiltration of lymphocytes, histological grade, and prognosis. Hematoxylin and eosin-stained sections were histologically graded using the Elston and Ellis grading method. MHC class I expression on tumor cells was evaluated using the avidin-biotin peroxidase complex method. Loss of MHC class I expression from canine mammary gland carcinomas was significantly correlated with poor prognosis (P<0.05). Loss of MHC class I expression showed no association with poor prognosis in canine mammary gland complex carcinomas because the data was not balanced. Only 1 of 13 (7.6%) canine mammary complex carcinomas showed loss of MHC class I expression. All 13 of these dogs showed good prognosis. Thus, the low frequency of MHC class I expression loss from canine mammary gland complex carcinomas may be associated with good prognosis. Taken together, these results suggest that loss of MHC class I expression may be associated with poor prognosis in canine mammary gland carcinomas.
著者
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Hoshi Fumio
Department Of Small Animal Internal Medicine School Of Veterinary Medicine Kitasato University
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Tanaka Toshiyuki
Laboratory Of Immunodynamics Department Of Microbiology And Immunology Osaka University Graduate Sch
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Shimada Terumasa
Veterinary Teaching Hospital College Of Agriculture Osaka Prefecture University
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Kuwamura Mitsuru
Laboratory Of Veterinary Pathology Osaka Prefecture University
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Shimizu Junichiro
Laboratory Of Veterinary Surgery Osaka Prefecture University
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Akiyoshi Hideo
Laboratory Of Veterinary Surgery Osaka Prefecture University
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Ohashi Fumihito
Laboratory Of Veterinary Surgery Osaka Prefecture University
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TANAKA Toshiyuki
Laboratory of Veterinary Surgery, Department of Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1–58 Rinku-Oraikita, Izumisano, Osaka 598–8531, Japan
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ZHENG Cao
Laboratory of Veterinary Surgery, Department of Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1–58 Rinku-Oraikita, Izumisano, Osaka 598–8531, Japan
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YIJYUN Li
Laboratory of Veterinary Surgery, Department of Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1–58 Rinku-Oraikita, Izumisano, Osaka 598–8531, Japan
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MIE Keiichiro
Laboratory of Veterinary Surgery, Department of Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1–58 Rinku-Oraikita, Izumisano, Osaka 598–8531, Japan
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HAYASHI Akiyoshi
Laboratory of Veterinary Surgery, Department of Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1–58 Rinku-Oraikita, Izumisano, Osaka 598–8531, Japan
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HAYASHI Akiyoshi
Laboratory of Veterinary Surgery, Department of Advanced Clinical Medicine, Course of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1–58 Rinku-Orai-Kita, Izumisano, Osaka 598–8531, Japan
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SHIMIZU Junichiro
Laboratory of Veterinary Surgery, Department of Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1–58 Rinku-Oraikita, Izumisano, Osaka 598–8531, Japan
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SHIMADA Terumasa
Veterinary Medical Center, Department of Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1–58 Rinku-Oraikita, Izumisano, Osaka 598–8531, Japan
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AKIYOSHI Hideo
Laboratory of Veterinary Surgery, Department of Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1–58 Rinku-Oraikita, Izumisano, Osaka 598–8531, Japan
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